Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2190931..2191569 Replicon chromosome
Accession NZ_CP091065
Organism Escherichia coli strain DOC14

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag L1123_RS10655 Protein ID WP_000813794.1
Coordinates 2191393..2191569 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L1123_RS10650 Protein ID WP_001270286.1
Coordinates 2190931..2191347 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1123_RS10630 (2186083) 2186083..2187024 - 942 WP_001251304.1 ABC transporter permease -
L1123_RS10635 (2187025) 2187025..2188038 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
L1123_RS10640 (2188056) 2188056..2189201 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
L1123_RS10645 (2189446) 2189446..2190852 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
L1123_RS10650 (2190931) 2190931..2191347 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
L1123_RS10655 (2191393) 2191393..2191569 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
L1123_RS10660 (2191791) 2191791..2192021 + 231 WP_000494244.1 YncJ family protein -
L1123_RS10665 (2192113) 2192113..2194074 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
L1123_RS10670 (2194147) 2194147..2194683 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
L1123_RS10675 (2194736) 2194736..2195950 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T232629 WP_000813794.1 NZ_CP091065:c2191569-2191393 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T232629 NZ_CP127848:294469-294699 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT232629 WP_001270286.1 NZ_CP091065:c2191347-2190931 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT232629 NZ_CP127848:294696-295055 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References