Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4210168..4210787 Replicon chromosome
Accession NZ_CP091061
Organism Klebsiella pneumoniae strain KP29105

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag L1062_RS20375 Protein ID WP_002892050.1
Coordinates 4210569..4210787 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag L1062_RS20370 Protein ID WP_002892066.1
Coordinates 4210168..4210542 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1062_RS20360 (4205320) 4205320..4206513 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1062_RS20365 (4206536) 4206536..4209682 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
L1062_RS20370 (4210168) 4210168..4210542 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
L1062_RS20375 (4210569) 4210569..4210787 + 219 WP_002892050.1 HHA domain-containing protein Toxin
L1062_RS20380 (4210946) 4210946..4211512 + 567 WP_002892030.1 maltose O-acetyltransferase -
L1062_RS20385 (4211484) 4211484..4211624 - 141 WP_004147370.1 hypothetical protein -
L1062_RS20390 (4211645) 4211645..4212115 + 471 WP_002892026.1 YlaC family protein -
L1062_RS20395 (4212090) 4212090..4213541 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
L1062_RS20400 (4213642) 4213642..4214340 + 699 WP_002892021.1 GNAT family protein -
L1062_RS20405 (4214337) 4214337..4214477 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
L1062_RS20410 (4214477) 4214477..4214740 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T232601 WP_002892050.1 NZ_CP091061:4210569-4210787 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T232601 NZ_CP127403:c166159-164837 [Stenotrophomonas sp. As-5]
ATGGGTACGTTGCGGGTCTGGATGAATGGTGTCGAGGTAGCGCTCTGGGATGATGCGCGGAACCGGGCATCCCGCCTTTC
CTACCTCAGCCAATGGATTGGTTCGACGCAGTCGCGACCGCTGTCCCTTTCGCTCCCCCTGCTGCCCGACGGTGAAAGCC
ATCAAGGTCAGGTGGTCAACGACTACTTCGACAATCTTCTCCCCGATAACGTCACCATCCGCAACCGGATCCGCGACCGG
TTCGCCACGCGCAGCAGCAATACGTTCGATCTGCTTGAAGCCATTGGCCGGGATTGTGTGGGCGCGGTGCAGCTGTTGCC
ACATTCGCGCACACCGGATGCCATCCAGCGGATAACGTTCGAACCATTGAATGACTCAGGCGTCGCTGAAGTCCTGCGCC
AGGTCACAACAAGTGCATTGCCTGGCACTTCTTCCAGCGACGATGCGTTCCGCATTTCCATCGCTGGAGCGCAGGAAAAG
ACCGGCCTGCTGCTGCACGATGGTCAATGGTGCATTCCTACCGGAAGTACGCCGTCCACGCACATCTTCAAGCTGCCGTT
GGGTATCGTCGGCAACATGCGTGCGGACATGCACCAGTCCGTGGAGAACGAGTGGCTGTGCATGCACCTGCTGGCAGCCT
TTGGAATTCCCGTCGCGGATACGCAGATGGGGCGTTTTGAAGATCAAGGTGCACTGATCGTCGAACGTTTCGACCGGCGA
CTGGCTGCGGATCGCGTGTGGTGGCTTCGCTTGCCGCAGGAAGATATGTGTCAGGTCTTTGGCCTCCCCGCTGCCCGGAA
GTACGAATCCGATGGCGGCCCCGGCATCGTGGCCATCATGGATCTGCTTCGGCAATCCGAGCAGCCTGAGGATCGAGCAA
CCTTCTTCAAGACGCAGATCCTGTTCTGGATGCTTGCCGCGACCGACGGCCACGCAAAGAACTTCAGCGTCCACATCGAC
GCGGGTGGGCGTTTCCGTCTGACTCCTGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCCGGGGGCCCAATCAACT
CGATCCGCACAACGCGCAGCTTGCCATGGCGGTAGAGGGCAAGAACCGCCATCGAAAACTGCATCTTGTGCGACGCCGGC
ACTGGAACGAAACCGCACGTGCCTGTGGCGTAGCCGATGGCGCAGAGCCATGGATCGAAGCGTTGATCGCTTCCGTGGAG
CCCGCCATCGAACACGTCACACGCCAGCTTCCAAGCGGCTTCCCTTCGACCGTGTCCGAACCTGTTTTCAAGGGACTGCG
TGCTGCGGCGACCCGCCTTTCCAGCATGGCCCCCGACGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT232601 WP_002892066.1 NZ_CP091061:4210168-4210542 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT232601 NZ_CP127403:c166420-166163 [Stenotrophomonas sp. As-5]
ATGGACAGGCCGCCGCATACGGTGAGAACACCGCAGCAACTTGCGCCGCTGATGCGCGCGTTCAGACGCCAGGCCGGGCT
GAGTCAAGCACAGCTTGCCGAGCGACTGGGCATCTCCCGCCAGGCAGTCGGCGCATTGGAACGCGATCCAGCGTCTGCCA
GCTTCGAGCGATTGATGCGAGTCTGGGCCGTGTTGGGCCTGGAAATCAGCCTGCAGCAGCGAAGTCCCCGGGAAAACACG
TCGACTTCGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References