Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2780675..2782263 Replicon chromosome
Accession NZ_CP091061
Organism Klebsiella pneumoniae strain KP29105

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag L1062_RS13510 Protein ID WP_014907613.1
Coordinates 2780675..2781997 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag L1062_RS13515 Protein ID WP_002904790.1
Coordinates 2781997..2782263 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1062_RS13495 (2775731) 2775731..2778232 + 2502 WP_014907611.1 fimbria/pilus outer membrane usher protein -
L1062_RS13500 (2778220) 2778220..2779224 + 1005 WP_014907612.1 fimbrial protein -
L1062_RS13505 (2779366) 2779366..2780658 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
L1062_RS13510 (2780675) 2780675..2781997 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
L1062_RS13515 (2781997) 2781997..2782263 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
L1062_RS13520 (2782501) 2782501..2782827 - 327 WP_004215084.1 hydroxyisourate hydrolase -
L1062_RS13525 (2782824) 2782824..2783324 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
L1062_RS13530 (2783302) 2783302..2784681 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
L1062_RS13535 (2785027) 2785027..2786181 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
L1062_RS13540 (2786162) 2786162..2787085 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T232600 WP_014907613.1 NZ_CP091061:c2781997-2780675 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T232600 NZ_CP127390:c2765107-2764805 [Propionimicrobium sp. PCR01-08-3]
ATGGTGGAGGTCGTCAAGAGTACGACGTTTGACCGTTGGCTGACCAGACTTAGGGACCGGCAGGGTGCTGGTCGTATCTT
GGCAAGGATCGATCGTCTCTCTGCTGGTAATCGTGGTGATGCGAAATCGGTCGGAGCCGGGATTTGGGAGTTGCGCATCG
ATTATGGGCCCGGATATCGGGTCTACTACTTGCAACGTGGTTCCCGGCTGATTTTGTTGCTGTGTGGTGGCGACAAGTCA
AGCCAACAGCGCGATATTGAGAACGCGCACCGCATCGCTCGGGAATGGATAAGCAATGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT232600 WP_002904790.1 NZ_CP091061:c2782263-2781997 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT232600 NZ_CP127390:c2764812-2764513 [Propionimicrobium sp. PCR01-08-3]
ATGAATGATTCGGCTGAGCAATTTAGCTCCTATGACGGTGCCGACTATCTGAGTAGCCTTGGCGACGCTGCTGCCTATCT
GGAGGCGACGCTCGAAGATAGCGACGATCCGGCCCTGATCGCGAATGCGCTGGGTACGATTGCCCGCTCCGGCAATCTCA
GCCAGCTTGCCCGCCGAGTGGGCATGAGCCGGGAGGGGCTCTATAAGGCGCTTTCCGCAGACGGTAATCCTAGCTTTGCC
ACCATTATGAAAGTCGCGAGCGCGCTGGGACTCAAGCTTCACTTCGAGACGGTCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References