Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4971832..4972348 Replicon chromosome
Accession NZ_CP091058
Organism Klebsiella pneumoniae strain KP30086

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag L1063_RS23955 Protein ID WP_004178374.1
Coordinates 4971832..4972116 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L1063_RS23960 Protein ID WP_002886901.1
Coordinates 4972106..4972348 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1063_RS23930 (4967228) 4967228..4967491 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
L1063_RS23935 (4967621) 4967621..4967794 + 174 WP_041169004.1 hypothetical protein -
L1063_RS23940 (4967797) 4967797..4968540 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L1063_RS23945 (4968897) 4968897..4971035 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L1063_RS23950 (4971364) 4971364..4971828 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1063_RS23955 (4971832) 4971832..4972116 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1063_RS23960 (4972106) 4972106..4972348 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L1063_RS23965 (4972426) 4972426..4974336 - 1911 WP_012737231.1 PRD domain-containing protein -
L1063_RS23970 (4974359) 4974359..4975513 - 1155 WP_012737230.1 lactonase family protein -
L1063_RS23975 (4975580) 4975580..4976320 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T232583 WP_004178374.1 NZ_CP091058:c4972116-4971832 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T232583 NZ_CP127390:c35377-35084 [Propionimicrobium sp. PCR01-08-3]
ATGGCGCTAACGATAGAAGCATGGGACCCGAGCGAGCATCTTGAGACCCAGGATGACGTGGTGGCATATCTGAATGCGGC
ACTTGAAGACGGCGACCCGGCACTCCTGCAAGCTGCACTCGGCGACATCGCGAAGGCTCGGGGAATGAGCAGCATTGCTC
GCGAGGCAGGGGTTGGACGCGAGTCTCTCTACAAGTCATTGCGCATTGACGGCAACCCTTCGTGGCAAACCATCACCAAA
GTCCTCGCCGCCCTCGATATCCGGCTCGAAGCCAAGGCACCGGCTAACGCGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT232583 WP_002886901.1 NZ_CP091058:c4972348-4972106 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT232583 NZ_CP127390:c35682-35368 [Propionimicrobium sp. PCR01-08-3]
ATGAGGATACTTCGAACGGAGGTCTACGAGCGGTGGTTCCGCCGTTTGAAGGATGCTCAAGGAAAGGCGCGAATCGACAT
CGCGTTACGCCGCTGCACCCTGGTCGGAAGTGTTGTCGGCGATATCAAGCCGGTAGGTGACGGTGTTCAGGAAATGCGGA
TCCACTCGGGGCCGGGATATCGGGTCTACTTCCTGCACCGTCCGAATGAGCTAATGCTCCTGGTAATCGGCGGAGACAAA
TCCAGTCAGTCCCGAGACATAGAGAAAGCAAAAGCCATCGCGAAACAGCTGAAGGAGGAAGGACAATGGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References