Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797677..798334 Replicon chromosome
Accession NZ_CP091058
Organism Klebsiella pneumoniae strain KP30086

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L1063_RS03960 Protein ID WP_002916310.1
Coordinates 797924..798334 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L1063_RS03955 Protein ID WP_002916312.1
Coordinates 797677..797943 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1063_RS03930 (792885) 792885..794318 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L1063_RS03935 (794437) 794437..795165 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
L1063_RS03940 (795215) 795215..795526 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
L1063_RS03945 (795690) 795690..796349 + 660 WP_002916317.1 hemolysin III family protein -
L1063_RS03950 (796448) 796448..797431 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
L1063_RS03955 (797677) 797677..797943 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L1063_RS03960 (797924) 797924..798334 + 411 WP_002916310.1 protein YgfX Toxin
L1063_RS03965 (798341) 798341..798862 - 522 WP_002916308.1 flavodoxin FldB -
L1063_RS03970 (798963) 798963..799859 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L1063_RS03975 (799882) 799882..800595 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L1063_RS03980 (800601) 800601..802334 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T232571 WP_002916310.1 NZ_CP091058:797924-798334 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T232571 NZ_CP127380:c11551-11267 [Xanthomonas fragariae]
GTGCCACACCTGATTTGGACGCCGCCGGCACTCGCGGACGTTCAACGCCTGTATCGTTTCCTTGCTCCGAAGGATGCCGA
CGCTGCCCGCCGTGCGGTGCAAGCAATCCGCGCGCAGGTCAAAATCCTGGCGCATCAGCCTCGCATCGGGCGACCCGTCG
AGGACATGGCCCCCGAGTTCCGCGATTGGCTCATCGACTTTGGCGATAGCGGCTACGTGGCCCGGTATCGCATCAACGAA
AACATGGTGACGATCTTGGCCGTTCGGCACCAAAAGGAAGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT232571 WP_002916312.1 NZ_CP091058:797677-797943 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT232571 NZ_CP127380:c11817-11539 [Xanthomonas fragariae]
ATGGCATCGCCAACCTCGCTCAAGCTCGATGACGAGCTGAAAGGGCGTGTGCAACACCTCGCCCAAACCCAGCGCCGCAC
GCCGCACTGGATCATGCGTGAAGCCATTGCGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGACCTTCAAACAAGACGCGC
TCCGCGCTTGGGAGGACTATCAGCGCACCGGCCTGCACCTGACGCTCGAAGAAACCGATGCGTGGCTGGCCAAGCTCGAA
GCTGGCGAGGATGCGGAACTGCCAGCGTGCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References