232565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 57957..58479 Replicon plasmid pSW25KPC2
Accession NZ_CP091049
Organism Klebsiella pneumoniae strain AHSWKP25

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag L1P15_RS25780 Protein ID WP_014839901.1
Coordinates 58195..58479 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag L1P15_RS25775 Protein ID WP_014839900.1
Coordinates 57957..58205 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P15_RS25750 (L1P15_25750) 53135..53491 + 357 WP_017901071.1 hypothetical protein -
L1P15_RS25755 (L1P15_25755) 53865..54263 + 399 WP_014839899.1 H-NS family nucleoid-associated regulatory protein -
L1P15_RS25760 (L1P15_25760) 54400..55008 + 609 WP_024266306.1 DUF2913 family protein -
L1P15_RS25765 (L1P15_25765) 55552..56184 + 633 WP_001567369.1 hypothetical protein -
L1P15_RS25770 (L1P15_25770) 56213..57616 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
L1P15_RS25775 (L1P15_25775) 57957..58205 + 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1P15_RS25780 (L1P15_25780) 58195..58479 + 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1P15_RS25785 (L1P15_25785) 58670..59146 + 477 WP_042934526.1 hypothetical protein -
L1P15_RS25790 (L1P15_25790) 59152..59829 + 678 WP_042934501.1 hypothetical protein -
L1P15_RS29025 59846..60565 - 720 WP_042934502.1 cation:proton antiporter -
L1P15_RS25805 (L1P15_25805) 60806..61408 - 603 WP_014839902.1 HAD domain-containing protein -
L1P15_RS25810 (L1P15_25810) 61405..61926 - 522 WP_048336588.1 hypothetical protein -
L1P15_RS25815 (L1P15_25815) 62007..62951 - 945 WP_014839903.1 DsbA family protein -
L1P15_RS25820 (L1P15_25820) 63014..63223 - 210 WP_125316032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaKPC-2 / aac(3)-IId / ARR-3 / dfrA27 / aadA16 / qacE / sul1 / qnrB4 - 1..248847 248847
- flank IS/Tn - - 56213..57616 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T232565 WP_014839901.1 NZ_CP091049:58195-58479 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T232565 NZ_CP127376:2291191-2291931 [Bacillus arachidis]
TTGACAGTCTCTAACATTCGAATTGGTTTGTTTTTTCTTGTACTAGTTTTTTTATTTCTTATTTTCTTTTATTGGAAAAA
TGAAGAGTTGTACGAAGAGAAAAAACAGCTGATTCGAAAAACATGGTATGGTGTTTTTATTACATCAGTCACAATTTATT
TCATGGTGAAAGGAATTGATTTAACCCTCTGGAAAAACATTTTAATGTTCGTTGCAATGGTCATATTTGTTGATATTGCG
TTTATTTTAACTCCAAACATTTCGGAAATATGGGGGGCGAAATTTAGTGATATTGGAAAGACCGTTCAATCTATTAAACG
ATCATTAATTGCTTCGAAAGCACGAGGTGAAATTTACACAACAATTATTCAAAATGTAAACCCAGTGGCATTTGGGACGA
TGGAGTGGCAAACTGAAACAGAGTATGCAAAAAGCTTAAATGTATTTCTTGATACGTATGGTGAAAAAATTGGAGCAAAA
ATCGTTGTATTTGTGACAGCCAATGAATTAAATACAAATTTCCGTGGTATCCGCTCTCAATTTAGTATTACAGTACCTTT
AGAACATATAGAGCAGTTAAATGCACAAAAAGCAGTGCAGGTTGAAAATGTTGGTATTATACCAGCGAAAATAGTAAAAG
ATGTTTGTATTGTTATTGATGGTCAAAAGAACAATCTTCAAGATCGGGATTTTGAAAATGTATATAATTTAACGATTCAT
CATAGTTATTTTAGTAAATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT232565 WP_014839900.1 NZ_CP091049:57957-58205 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT232565 NZ_CP127376:2292053-2292181 [Bacillus arachidis]
GTGGAAAAAGAATATAGTAATGAATTTTTCAAAGAAGAAACTGAGGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTAGAAAGTTTAGAAGAAGAATTAAAAAGAAACGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References