232562

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4667898..4668414 Replicon chromosome
Accession NZ_CP091048
Organism Klebsiella pneumoniae strain AHSWKP25

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag L1P15_RS22700 Protein ID WP_004178374.1
Coordinates 4667898..4668182 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L1P15_RS22705 Protein ID WP_002886901.1
Coordinates 4668172..4668414 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P15_RS22675 (4663315) 4663315..4663578 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
L1P15_RS22680 (4663708) 4663708..4663881 + 174 WP_032431440.1 hypothetical protein -
L1P15_RS22685 (4663884) 4663884..4664627 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L1P15_RS22690 (4664984) 4664984..4667122 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L1P15_RS22695 (4667430) 4667430..4667894 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1P15_RS22700 (4667898) 4667898..4668182 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1P15_RS22705 (4668172) 4668172..4668414 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L1P15_RS22710 (4668492) 4668492..4670402 - 1911 WP_151503191.1 PRD domain-containing protein -
L1P15_RS22715 (4670425) 4670425..4671579 - 1155 WP_151503190.1 lactonase family protein -
L1P15_RS22720 (4671646) 4671646..4672386 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T232562 WP_004178374.1 NZ_CP091048:c4668182-4667898 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T232562 NZ_CP127363:c4739391-4738978 [Paracidovorax citrulli]
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT232562 WP_002886901.1 NZ_CP091048:c4668414-4668172 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT232562 NZ_CP127363:c4739611-4739378 [Paracidovorax citrulli]
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References