Detailed information of TA system TA232559

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2691966..2693554
• Replicon: chromosome
• Accession: NZ_CP091048
• Organism: Klebsiella pneumoniae strain AHSWKP25

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: L1P15_RS13285
• Protein ID: WP_087830461.1
• Coordinates: 2691966..2693288 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: L1P15_RS13290
• Protein ID: WP_002904790.1
• Coordinates: 2693288..2693554 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1P15_RS13270 (2687022)	2687022..2689523	+	2502	WP_151503050.1	fimbria/pilus outer membrane usher protein	-
L1P15_RS13275 (2689511)	2689511..2690515	+	1005	WP_151503049.1	fimbrial protein	-
L1P15_RS13280 (2690657)	2690657..2691949	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
L1P15_RS13285 (2691966)	2691966..2693288	-	1323	WP_087830461.1	type II toxin-antitoxin system HipA family toxin	Toxin
L1P15_RS13290 (2693288)	2693288..2693554	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
L1P15_RS13295 (2693819)	2693819..2694145	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
L1P15_RS13300 (2694142)	2694142..2694642	-	501	WP_151503048.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
L1P15_RS13305 (2694620)	2694620..2695999	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
L1P15_RS13310 (2696345)	2696345..2697499	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
L1P15_RS13315 (2697480)	2697480..2698403	-	924	WP_032436334.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49201.49 Da
• Isoelectric Point: 7.5357

>T232559 WP_087830461.1 NZ_CP091048:c2693288-2691966 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T232559 NZ_CP127362:614171-614584 [Paracidovorax citrulli]
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT232559 WP_002904790.1 NZ_CP091048:c2693554-2693288 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT232559 NZ_CP127362:613951-614184 [Paracidovorax citrulli]
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8