232550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795782..796439 Replicon chromosome
Accession NZ_CP091048
Organism Klebsiella pneumoniae strain AHSWKP25

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag L1P15_RS03940 Protein ID WP_002916310.1
Coordinates 796029..796439 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L1P15_RS03935 Protein ID WP_002916312.1
Coordinates 795782..796048 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P15_RS03910 (790938) 790938..792371 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L1P15_RS03915 (792490) 792490..793218 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L1P15_RS03920 (793268) 793268..793579 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L1P15_RS03925 (793743) 793743..794402 + 660 WP_002916317.1 hemolysin III family protein -
L1P15_RS03930 (794553) 794553..795536 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L1P15_RS03935 (795782) 795782..796048 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L1P15_RS03940 (796029) 796029..796439 + 411 WP_002916310.1 protein YgfX Toxin
L1P15_RS03945 (796446) 796446..796967 - 522 WP_004144730.1 flavodoxin FldB -
L1P15_RS03950 (797068) 797068..797964 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L1P15_RS03955 (797987) 797987..798700 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L1P15_RS03960 (798706) 798706..800439 + 1734 WP_151502932.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T232550 WP_002916310.1 NZ_CP091048:796029-796439 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T232550 NZ_CP127317:c47987-47838 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT232550 WP_002916312.1 NZ_CP091048:795782-796048 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT232550 NZ_CP127317:48036-48092 [Escherichia coli]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References