Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3816048..3816666 Replicon chromosome
Accession NZ_CP091044
Organism Escherichia coli strain STEC346

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L1P11_RS19260 Protein ID WP_001291435.1
Coordinates 3816448..3816666 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L1P11_RS19255 Protein ID WP_000344800.1
Coordinates 3816048..3816422 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P11_RS19245 (3811137) 3811137..3812330 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1P11_RS19250 (3812353) 3812353..3815502 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L1P11_RS19255 (3816048) 3816048..3816422 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L1P11_RS19260 (3816448) 3816448..3816666 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L1P11_RS19265 (3816838) 3816838..3817389 + 552 WP_000102568.1 maltose O-acetyltransferase -
L1P11_RS19270 (3817505) 3817505..3817975 + 471 WP_000136192.1 YlaC family protein -
L1P11_RS19275 (3818139) 3818139..3819689 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L1P11_RS19280 (3819731) 3819731..3820084 - 354 WP_000878140.1 DUF1428 domain-containing protein -
L1P11_RS19290 (3820463) 3820463..3820774 + 312 WP_000409911.1 MGMT family protein -
L1P11_RS19295 (3820805) 3820805..3821377 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T232529 WP_001291435.1 NZ_CP091044:3816448-3816666 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T232529 NZ_CP127316:c654485-654207 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGCCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGTGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT232529 WP_000344800.1 NZ_CP091044:3816048-3816422 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT232529 NZ_CP127316:c654207-653923 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACACCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References