Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 750282..751117 Replicon chromosome
Accession NZ_CP091044
Organism Escherichia coli strain STEC346

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag L1P11_RS03725 Protein ID WP_235411820.1
Coordinates 750740..751117 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag L1P11_RS03720 Protein ID WP_235411818.1
Coordinates 750282..750650 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P11_RS03695 (747681) 747681..747914 + 234 WP_235411976.1 DUF905 family protein -
L1P11_RS03700 (748007) 748007..748825 + 819 WP_097308925.1 DUF932 domain-containing protein -
L1P11_RS03705 (748917) 748917..749402 + 486 WP_235411816.1 antirestriction protein -
L1P11_RS03710 (749418) 749418..749894 + 477 WP_071045793.1 RadC family protein -
L1P11_RS03715 (749981) 749981..750202 + 222 WP_000692350.1 DUF987 domain-containing protein -
L1P11_RS03720 (750282) 750282..750650 + 369 WP_235411818.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L1P11_RS03725 (750740) 750740..751117 + 378 WP_235411820.1 TA system toxin CbtA family protein Toxin
L1P11_RS03730 (751114) 751114..751602 + 489 WP_000761678.1 DUF5983 family protein -
L1P11_RS03735 (751614) 751614..751811 + 198 WP_000839239.1 DUF957 domain-containing protein -
L1P11_RS03740 (751896) 751896..752741 + 846 WP_235411822.1 DUF4942 domain-containing protein -
L1P11_RS03750 (753040) 753040..753546 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
L1P11_RS03755 (753625) 753625..755466 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(20-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14128.10 Da        Isoelectric Point: 8.5252

>T232513 WP_235411820.1 NZ_CP091044:750740-751117 [Escherichia coli]
MNTLPDTHVREASRRPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T232513 NZ_CP127314:3035404-3035682 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13580.36 Da        Isoelectric Point: 6.6258

>AT232513 WP_235411818.1 NZ_CP091044:750282-750650 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWRGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT232513 NZ_CP127314:3035682-3035966 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References