Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 65862..66421 Replicon plasmid p2_STEC384
Accession NZ_CP091031
Organism Escherichia coli strain STEC384

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L1P14_RS26080 Protein ID WP_032084131.1
Coordinates 66146..66421 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L1P14_RS26075 Protein ID WP_032084130.1
Coordinates 65862..66146 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P14_RS26050 (63266) 63266..63958 + 693 WP_062886836.1 fimbrial chaperone -
L1P14_RS26055 (64074) 64074..64451 + 378 WP_235399558.1 hypothetical protein -
L1P14_RS26060 (64602) 64602..65444 + 843 WP_064578920.1 hypothetical protein -
L1P14_RS26065 (65500) 65500..65625 - 126 Protein_84 IS256 family transposase -
L1P14_RS26070 (65697) 65697..65777 - 81 Protein_85 ATP-binding protein -
L1P14_RS26075 (65862) 65862..66146 + 285 WP_032084130.1 ribbon-helix-helix domain-containing protein Antitoxin
L1P14_RS26080 (66146) 66146..66421 + 276 WP_032084131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1P14_RS26085 (66527) 66527..66730 + 204 Protein_88 hypothetical protein -
L1P14_RS26090 (67078) 67078..67425 + 348 WP_235399559.1 DUF6404 family protein -
L1P14_RS26095 (67443) 67443..67877 - 435 Protein_90 hypothetical protein -
L1P14_RS26100 (68161) 68161..69084 - 924 WP_032084040.1 hypothetical protein -
L1P14_RS26105 (69977) 69977..70750 - 774 WP_032084041.1 YaiO family outer membrane beta-barrel protein -
L1P14_RS26110 (70752) 70752..71222 - 471 WP_235399562.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..71807 71807
- flank IS/Tn - - 71232..71735 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10765.45 Da        Isoelectric Point: 9.9324

>T232507 WP_032084131.1 NZ_CP091031:66146-66421 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFSGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T232507 NZ_CP127314:2317600-2317851 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.92 Da        Isoelectric Point: 5.6558

>AT232507 WP_032084130.1 NZ_CP091031:65862-66146 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQTW
ADSLNTDNPLPVPR

Download         Length: 285 bp

>AT232507 NZ_CP127314:2317848-2318102 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References