Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3696388..3697006 Replicon chromosome
Accession NZ_CP091029
Organism Escherichia coli strain STEC384

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L1P14_RS18385 Protein ID WP_001291435.1
Coordinates 3696788..3697006 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L1P14_RS18380 Protein ID WP_000344800.1
Coordinates 3696388..3696762 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P14_RS18370 (3691477) 3691477..3692670 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1P14_RS18375 (3692693) 3692693..3695842 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L1P14_RS18380 (3696388) 3696388..3696762 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L1P14_RS18385 (3696788) 3696788..3697006 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L1P14_RS18390 (3697177) 3697177..3697728 + 552 WP_000102578.1 maltose O-acetyltransferase -
L1P14_RS18395 (3697844) 3697844..3698314 + 471 WP_000136192.1 YlaC family protein -
L1P14_RS18400 (3698478) 3698478..3700028 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L1P14_RS18405 (3700070) 3700070..3700423 - 354 WP_000878140.1 DUF1428 domain-containing protein -
L1P14_RS18415 (3700802) 3700802..3701113 + 312 WP_000409911.1 MGMT family protein -
L1P14_RS18420 (3701144) 3701144..3701716 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T232496 WP_001291435.1 NZ_CP091029:3696788-3697006 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T232496 NZ_CP127306:4185425-4185532 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT232496 WP_000344800.1 NZ_CP091029:3696388-3696762 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT232496 NZ_CP127306:c4185375-4185312 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References