Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1931838..1932309 | Replicon | chromosome |
| Accession | NZ_CP091029 | ||
| Organism | Escherichia coli strain STEC384 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | L1P14_RS09420 | Protein ID | WP_001303511.1 |
| Coordinates | 1931838..1932116 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | L1P14_RS09425 | Protein ID | WP_001302048.1 |
| Coordinates | 1932118..1932309 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1P14_RS09390 (1927245) | 1927245..1927448 | - | 204 | WP_000096344.1 | DUF4224 domain-containing protein | - |
| L1P14_RS09395 (1927507) | 1927507..1929978 | - | 2472 | WP_235399511.1 | exonuclease | - |
| L1P14_RS09400 (1930074) | 1930074..1930262 | - | 189 | WP_000199480.1 | DUF1482 family protein | - |
| L1P14_RS09405 (1930259) | 1930259..1930447 | - | 189 | WP_000449172.1 | cell division inhibition protein DicB | - |
| L1P14_RS09410 (1931013) | 1931013..1931231 | - | 219 | WP_001171958.1 | protein YdfC | - |
| L1P14_RS26135 (1931261) | 1931261..1931389 | - | 129 | WP_000344925.1 | hypothetical protein | - |
| L1P14_RS09415 (1931391) | 1931391..1931546 | - | 156 | WP_000379589.1 | DUF1391 family protein | - |
| L1P14_RS09420 (1931838) | 1931838..1932116 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L1P14_RS09425 (1932118) | 1932118..1932309 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| L1P14_RS09430 (1932330) | 1932330..1932701 | - | 372 | WP_001169685.1 | hypothetical protein | - |
| L1P14_RS09435 (1932799) | 1932799..1933101 | + | 303 | WP_000172735.1 | transcriptional regulator | - |
| L1P14_RS09440 (1933098) | 1933098..1933523 | + | 426 | WP_235399512.1 | toxin YdaT family protein | - |
| L1P14_RS09445 (1933595) | 1933595..1934665 | + | 1071 | WP_235399513.1 | phage replisome organizer | - |
| L1P14_RS09450 (1934706) | 1934706..1935131 | + | 426 | WP_001151178.1 | DUF977 family protein | - |
| L1P14_RS09455 (1935128) | 1935128..1935328 | + | 201 | WP_001546006.1 | hypothetical protein | - |
| L1P14_RS09460 (1935399) | 1935399..1936096 | + | 698 | WP_103215986.1 | IS1-like element IS1A family transposase | - |
| L1P14_RS09465 (1936172) | 1936172..1936354 | + | 183 | WP_001224945.1 | hypothetical protein | - |
| L1P14_RS09470 (1936347) | 1936347..1936523 | + | 177 | WP_000753061.1 | hypothetical protein | - |
| L1P14_RS09475 (1936520) | 1936520..1937035 | + | 516 | WP_001289996.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1913753..1967377 | 53624 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T232486 WP_001303511.1 NZ_CP091029:c1932116-1931838 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T232486 NZ_CP127306:2545153-2545488 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGTTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGTGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGTTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGTGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT232486 WP_001302048.1 NZ_CP091029:c1932309-1932118 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT232486 NZ_CP127306:2544905-2545153 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|