Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1178509..1179304 | Replicon | chromosome |
Accession | NC_011601 | ||
Organism | Escherichia coli O127:H6 str. E2348/69 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | B7UP43 |
Locus tag | E2348C_RS05970 | Protein ID | WP_000854914.1 |
Coordinates | 1178930..1179304 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | B7UP42 |
Locus tag | E2348C_RS05965 | Protein ID | WP_001280955.1 |
Coordinates | 1178509..1178883 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E2348C_RS05925 (E2348_C_1111) | 1173864..1174769 | + | 906 | WP_000203541.1 | chemotaxis protein | - |
E2348C_RS05930 (E2348_C_1112) | 1174766..1175836 | + | 1071 | WP_000102671.1 | patatin-like phospholipase family protein | - |
E2348C_RS05940 (E2348_C_1114) | 1176176..1176994 | + | 819 | WP_001234664.1 | DUF945 domain-containing protein | - |
E2348C_RS05945 (E2348_C_1115) | 1177085..1177570 | + | 486 | WP_000214398.1 | antirestriction protein | - |
E2348C_RS05950 (E2348_C_1116) | 1177586..1178062 | + | 477 | WP_001186738.1 | RadC family protein | - |
E2348C_RS05955 (E2348_C_1117) | 1178125..1178346 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
E2348C_RS05965 (E2348_C_1118) | 1178509..1178883 | + | 375 | WP_001280955.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
E2348C_RS05970 (E2348_C_1119) | 1178930..1179304 | + | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
E2348C_RS05975 (E2348_C_1120) | 1179301..1179792 | + | 492 | WP_000976857.1 | hypothetical protein | - |
E2348C_RS05980 (E2348_C_1121) | 1179804..1180001 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
E2348C_RS05985 (E2348_C_1122) | 1180086..1180928 | + | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
E2348C_RS05995 (E2348_C_1123) | 1181398..1182336 | + | 939 | WP_000351277.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
E2348C_RS06000 (E2348_C_1124) | 1182391..1183128 | + | 738 | WP_000283657.1 | zinc-binding phosphatase | - |
E2348C_RS06005 (E2348_C_1125) | 1183152..1183706 | + | 555 | WP_001001921.1 | molecular chaperone YcdY | - |
E2348C_RS06010 (E2348_C_1126) | 1183808..1184299 | + | 492 | WP_001340063.1 | DUF1097 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T23248 WP_000854914.1 NC_011601:1178930-1179304 [Escherichia coli O127:H6 str. E2348/69]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T23248 NC_011601:1178930-1179304 [Escherichia coli O127:H6 str. E2348/69]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13767.59 Da Isoelectric Point: 6.6248
>AT23248 WP_001280955.1 NC_011601:1178509-1178883 [Escherichia coli O127:H6 str. E2348/69]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT23248 NC_011601:1178509-1178883 [Escherichia coli O127:H6 str. E2348/69]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LXR5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9P0D0 |