23248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1178509..1179304 Replicon chromosome
Accession NC_011601
Organism Escherichia coli O127:H6 str. E2348/69

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag E2348C_RS05970 Protein ID WP_000854914.1
Coordinates 1178930..1179304 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag E2348C_RS05965 Protein ID WP_001280955.1
Coordinates 1178509..1178883 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2348C_RS05925 (E2348_C_1111) 1173864..1174769 + 906 WP_000203541.1 chemotaxis protein -
E2348C_RS05930 (E2348_C_1112) 1174766..1175836 + 1071 WP_000102671.1 patatin-like phospholipase family protein -
E2348C_RS05940 (E2348_C_1114) 1176176..1176994 + 819 WP_001234664.1 DUF945 domain-containing protein -
E2348C_RS05945 (E2348_C_1115) 1177085..1177570 + 486 WP_000214398.1 antirestriction protein -
E2348C_RS05950 (E2348_C_1116) 1177586..1178062 + 477 WP_001186738.1 RadC family protein -
E2348C_RS05955 (E2348_C_1117) 1178125..1178346 + 222 WP_001220314.1 DUF987 domain-containing protein -
E2348C_RS05965 (E2348_C_1118) 1178509..1178883 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E2348C_RS05970 (E2348_C_1119) 1178930..1179304 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
E2348C_RS05975 (E2348_C_1120) 1179301..1179792 + 492 WP_000976857.1 hypothetical protein -
E2348C_RS05980 (E2348_C_1121) 1179804..1180001 + 198 WP_000839282.1 DUF957 domain-containing protein -
E2348C_RS05985 (E2348_C_1122) 1180086..1180928 + 843 WP_001280481.1 DUF4942 domain-containing protein -
E2348C_RS05995 (E2348_C_1123) 1181398..1182336 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
E2348C_RS06000 (E2348_C_1124) 1182391..1183128 + 738 WP_000283657.1 zinc-binding phosphatase -
E2348C_RS06005 (E2348_C_1125) 1183152..1183706 + 555 WP_001001921.1 molecular chaperone YcdY -
E2348C_RS06010 (E2348_C_1126) 1183808..1184299 + 492 WP_001340063.1 DUF1097 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T23248 WP_000854914.1 NC_011601:1178930-1179304 [Escherichia coli O127:H6 str. E2348/69]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T23248 NC_011601:1178930-1179304 [Escherichia coli O127:H6 str. E2348/69]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT23248 WP_001280955.1 NC_011601:1178509-1178883 [Escherichia coli O127:H6 str. E2348/69]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT23248 NC_011601:1178509-1178883 [Escherichia coli O127:H6 str. E2348/69]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References