Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4460529..4461124 Replicon chromosome
Accession NZ_CP091024
Organism Escherichia coli strain STEC379

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag L1P13_RS22000 Protein ID WP_000239579.1
Coordinates 4460529..4460879 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag L1P13_RS22005 Protein ID WP_001223207.1
Coordinates 4460873..4461124 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P13_RS21980 (4455805) 4455805..4456827 - 1023 WP_001296689.1 ABC transporter permease -
L1P13_RS21985 (4456841) 4456841..4458343 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
L1P13_RS21990 (4458653) 4458653..4459609 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
L1P13_RS21995 (4459919) 4459919..4460449 + 531 WP_000055072.1 inorganic diphosphatase -
L1P13_RS22000 (4460529) 4460529..4460879 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
L1P13_RS22005 (4460873) 4460873..4461124 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
L1P13_RS22010 (4461337) 4461337..4461678 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
L1P13_RS22015 (4461681) 4461681..4465460 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T232437 WP_000239579.1 NZ_CP091024:c4460879-4460529 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T232437 NZ_CP127297:3143541-3143648 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT232437 WP_001223207.1 NZ_CP091024:c4461124-4460873 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT232437 NZ_CP127297:c3143494-3143428 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References