Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3746880..3747498 Replicon chromosome
Accession NZ_CP091024
Organism Escherichia coli strain STEC379

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag L1P13_RS18640 Protein ID WP_001291435.1
Coordinates 3747280..3747498 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag L1P13_RS18635 Protein ID WP_000344800.1
Coordinates 3746880..3747254 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P13_RS18625 (3741969) 3741969..3743162 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1P13_RS18630 (3743185) 3743185..3746334 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
L1P13_RS18635 (3746880) 3746880..3747254 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
L1P13_RS18640 (3747280) 3747280..3747498 + 219 WP_001291435.1 HHA domain-containing protein Toxin
L1P13_RS18645 (3747669) 3747669..3748220 + 552 WP_000102578.1 maltose O-acetyltransferase -
L1P13_RS18650 (3748336) 3748336..3748806 + 471 WP_000136192.1 YlaC family protein -
L1P13_RS18655 (3748970) 3748970..3750520 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
L1P13_RS18660 (3750562) 3750562..3750915 - 354 WP_000878140.1 DUF1428 domain-containing protein -
L1P13_RS18670 (3751294) 3751294..3751605 + 312 WP_000409911.1 MGMT family protein -
L1P13_RS18675 (3751636) 3751636..3752208 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T232433 WP_001291435.1 NZ_CP091024:3747280-3747498 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T232433 NZ_CP127297:2485124-2485227 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT232433 WP_000344800.1 NZ_CP091024:3746880-3747254 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT232433 NZ_CP127297:c2485265-2484994 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References