Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1980773..1981244 | Replicon | chromosome |
| Accession | NZ_CP091024 | ||
| Organism | Escherichia coli strain STEC379 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | L1P13_RS09660 | Protein ID | WP_001303511.1 |
| Coordinates | 1980773..1981051 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | L1P13_RS09665 | Protein ID | WP_001302048.1 |
| Coordinates | 1981053..1981244 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1P13_RS09630 (1976180) | 1976180..1976383 | - | 204 | WP_000096344.1 | DUF4224 domain-containing protein | - |
| L1P13_RS09635 (1976442) | 1976442..1978913 | - | 2472 | WP_235399511.1 | exonuclease | - |
| L1P13_RS09640 (1979009) | 1979009..1979197 | - | 189 | WP_000199480.1 | DUF1482 family protein | - |
| L1P13_RS09645 (1979194) | 1979194..1979382 | - | 189 | WP_000449172.1 | cell division inhibition protein DicB | - |
| L1P13_RS09650 (1979948) | 1979948..1980166 | - | 219 | WP_001171958.1 | protein YdfC | - |
| L1P13_RS25215 (1980196) | 1980196..1980324 | - | 129 | WP_000344925.1 | hypothetical protein | - |
| L1P13_RS09655 (1980326) | 1980326..1980481 | - | 156 | WP_000379589.1 | DUF1391 family protein | - |
| L1P13_RS09660 (1980773) | 1980773..1981051 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L1P13_RS09665 (1981053) | 1981053..1981244 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| L1P13_RS09670 (1981265) | 1981265..1981636 | - | 372 | WP_001169685.1 | hypothetical protein | - |
| L1P13_RS09675 (1981734) | 1981734..1982036 | + | 303 | WP_000172735.1 | transcriptional regulator | - |
| L1P13_RS09680 (1982033) | 1982033..1982458 | + | 426 | WP_235399512.1 | toxin YdaT family protein | - |
| L1P13_RS09685 (1982530) | 1982530..1983600 | + | 1071 | WP_235399513.1 | phage replisome organizer | - |
| L1P13_RS09690 (1983641) | 1983641..1984066 | + | 426 | WP_001151178.1 | DUF977 family protein | - |
| L1P13_RS09695 (1984063) | 1984063..1984263 | + | 201 | WP_001546006.1 | hypothetical protein | - |
| L1P13_RS09700 (1984334) | 1984334..1985031 | + | 698 | WP_103215986.1 | IS1-like element IS1A family transposase | - |
| L1P13_RS09705 (1985135) | 1985135..1985317 | + | 183 | WP_001224945.1 | hypothetical protein | - |
| L1P13_RS09710 (1985310) | 1985310..1985486 | + | 177 | WP_000753061.1 | hypothetical protein | - |
| L1P13_RS09715 (1985483) | 1985483..1985998 | + | 516 | WP_001289996.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1973673..2016341 | 42668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T232423 WP_001303511.1 NZ_CP091024:c1981051-1980773 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T232423 NZ_CP127296:c6446475-6446113 [Amycolatopsis sp. DG1A-15b]
ATGGCCGGCCAGGACTGGGAAATCTATGTCGTAGACGAAGTCCTCGAGTGGATCGAGCGGCTGGACGATGCGACGCACGC
TCGTGTCGTGCAAGCGATCGACGCGCTGGCGGAGGGCGGCCCTGGCCTGGGGCGGCCGTTGGTCGACACGATCGTCGGGT
CTCGGATCCAGAACCTGAAGGAGCTGCGGCCCGGTACCGTGCGAATCCTGTTCGTCTTCGATCCCTGGCGAGCGAGTGTC
CTGCTCGTCGCCGGGGATAAGGCAGGGCGGTGGAATGCCTGGTACGGGGAGGCGATCCCACTGGCCGAGGATCGATATGA
CCGTTATCTGAAGGAACGCCAGGCAGAGGAAGGCCGACCATGA
ATGGCCGGCCAGGACTGGGAAATCTATGTCGTAGACGAAGTCCTCGAGTGGATCGAGCGGCTGGACGATGCGACGCACGC
TCGTGTCGTGCAAGCGATCGACGCGCTGGCGGAGGGCGGCCCTGGCCTGGGGCGGCCGTTGGTCGACACGATCGTCGGGT
CTCGGATCCAGAACCTGAAGGAGCTGCGGCCCGGTACCGTGCGAATCCTGTTCGTCTTCGATCCCTGGCGAGCGAGTGTC
CTGCTCGTCGCCGGGGATAAGGCAGGGCGGTGGAATGCCTGGTACGGGGAGGCGATCCCACTGGCCGAGGATCGATATGA
CCGTTATCTGAAGGAACGCCAGGCAGAGGAAGGCCGACCATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT232423 WP_001302048.1 NZ_CP091024:c1981244-1981053 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT232423 NZ_CP127296:c6446116-6445799 [Amycolatopsis sp. DG1A-15b]
ATGACGGGCTACACGCGTTGGAAGGATGTCCGTGCGACGCATGTCGAGCGGGCCGGCGGGGAGGAAGCAGTCGAGGCGGG
CAAGCAGGAGCTCCTCGCCGTGGTCCAGGGCCACCGCCTCGCCGAAATCCGCCGGGGTCGAGGCCTGACTCAGCAACAGC
TGGCCGACCGGATGGGCGTCACCAAGGGCCGGGTGTCCCAGATCGAACAGGGCAAGATCTCCGGCCTGGAGGTGCTCGCC
CGCTACGCTGCGGCTTTGGGTGGCCGTCTGCACCAGGCGATCTACTTCGAGGACGGGGATATCGCCGCCATCGCTTGA
ATGACGGGCTACACGCGTTGGAAGGATGTCCGTGCGACGCATGTCGAGCGGGCCGGCGGGGAGGAAGCAGTCGAGGCGGG
CAAGCAGGAGCTCCTCGCCGTGGTCCAGGGCCACCGCCTCGCCGAAATCCGCCGGGGTCGAGGCCTGACTCAGCAACAGC
TGGCCGACCGGATGGGCGTCACCAAGGGCCGGGTGTCCCAGATCGAACAGGGCAAGATCTCCGGCCTGGAGGTGCTCGCC
CGCTACGCTGCGGCTTTGGGTGGCCGTCTGCACCAGGCGATCTACTTCGAGGACGGGGATATCGCCGCCATCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|