Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1362104..1362729 Replicon chromosome
Accession NZ_CP091024
Organism Escherichia coli strain STEC379

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag L1P13_RS06610 Protein ID WP_000911329.1
Coordinates 1362331..1362729 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag L1P13_RS06605 Protein ID WP_000450524.1
Coordinates 1362104..1362331 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P13_RS06580 (1357906) 1357906..1358376 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
L1P13_RS06585 (1358376) 1358376..1358948 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
L1P13_RS06590 (1359094) 1359094..1359972 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
L1P13_RS06595 (1359989) 1359989..1361023 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
L1P13_RS06600 (1361236) 1361236..1361949 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
L1P13_RS06605 (1362104) 1362104..1362331 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
L1P13_RS06610 (1362331) 1362331..1362729 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
L1P13_RS06615 (1362876) 1362876..1363739 + 864 WP_136696826.1 neutral zinc metallopeptidase -
L1P13_RS06620 (1363754) 1363754..1365769 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
L1P13_RS06625 (1365843) 1365843..1366541 + 699 WP_000679823.1 esterase -
L1P13_RS06630 (1366651) 1366651..1366851 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T232421 WP_000911329.1 NZ_CP091024:1362331-1362729 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T232421 NZ_CP127277:c3781506-3781114 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT232421 WP_000450524.1 NZ_CP091024:1362104-1362331 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT232421 NZ_CP127277:c3781781-3781506 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References