Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2348038..2348564 | Replicon | chromosome |
| Accession | NZ_CP091022 | ||
| Organism | Escherichia coli strain STEC276 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L1O93_RS11355 | Protein ID | WP_000323025.1 |
| Coordinates | 2348277..2348564 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L1O93_RS11350 | Protein ID | WP_000534858.1 |
| Coordinates | 2348038..2348277 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1O93_RS11310 (2343221) | 2343221..2343451 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| L1O93_RS11315 (2343435) | 2343435..2343956 | + | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| L1O93_RS11320 (2343937) | 2343937..2344902 | + | 966 | WP_000054506.1 | hypothetical protein | - |
| L1O93_RS11325 (2344943) | 2344943..2345362 | + | 420 | WP_001151195.1 | DUF977 family protein | - |
| L1O93_RS11330 (2345417) | 2345417..2346466 | + | 1050 | Protein_2224 | ISNCY family transposase | - |
| L1O93_RS11335 (2346587) | 2346587..2346736 | + | 150 | WP_180302674.1 | protein YdfW | - |
| L1O93_RS11340 (2347173) | 2347173..2347505 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| L1O93_RS11345 (2347708) | 2347708..2348013 | - | 306 | WP_001326990.1 | protein YdfV | - |
| L1O93_RS11350 (2348038) | 2348038..2348277 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L1O93_RS11355 (2348277) | 2348277..2348564 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L1O93_RS11360 (2348636) | 2348636..2348791 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| L1O93_RS11365 (2349008) | 2349008..2349259 | + | 252 | WP_000980994.1 | protein Rem | - |
| L1O93_RS11370 (2349326) | 2349326..2349604 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| L1O93_RS11375 (2349606) | 2349606..2350655 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| L1O93_RS11380 (2350669) | 2350669..2351421 | + | 753 | WP_001047135.1 | antitermination protein | - |
| L1O93_RS11385 (2351699) | 2351699..2351788 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| L1O93_RS11390 (2351843) | 2351843..2352055 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| L1O93_RS11395 (2352356) | 2352356..2352571 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| L1O93_RS11400 (2352935) | 2352935..2353105 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| L1O93_RS11405 (2353325) | 2353325..2353540 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2332728..2390700 | 57972 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T232402 WP_000323025.1 NZ_CP091022:2348277-2348564 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T232402 NZ_CP127277:c2347141-2346707 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT232402 WP_000534858.1 NZ_CP091022:2348038-2348277 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT232402 NZ_CP127277:c2347402-2347148 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|