Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 835592..836427 Replicon chromosome
Accession NZ_CP091022
Organism Escherichia coli strain STEC276

Toxin (Protein)


Gene name yeeV Uniprot ID E3PD61
Locus tag L1O93_RS03995 Protein ID WP_001094449.1
Coordinates 835592..835969 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A826UXU4
Locus tag L1O93_RS04000 Protein ID WP_024210939.1
Coordinates 836059..836427 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O93_RS03970 (831765) 831765..832301 + 537 WP_001544090.1 GspM family type II secretion system protein YghD -
L1O93_RS03975 (832637) 832637..834064 - 1428 WP_240992397.1 EAL domain-containing protein -
L1O93_RS03980 (834243) 834243..835088 - 846 WP_001290172.1 DUF4942 domain-containing protein -
L1O93_RS03985 (835173) 835173..835370 - 198 WP_087891818.1 DUF957 domain-containing protein -
L1O93_RS03990 (835446) 835446..835595 - 150 Protein_787 DUF5983 family protein -
L1O93_RS03995 (835592) 835592..835969 - 378 WP_001094449.1 TA system toxin CbtA family protein Toxin
L1O93_RS04000 (836059) 836059..836427 - 369 WP_024210939.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L1O93_RS04005 (836477) 836477..837121 - 645 WP_001079776.1 hypothetical protein -
L1O93_RS04010 (837135) 837135..837356 - 222 WP_000692293.1 DUF987 domain-containing protein -
L1O93_RS04015 (837425) 837425..837901 - 477 WP_001186710.1 RadC family protein -
L1O93_RS04020 (837916) 837916..838401 - 486 WP_000206661.1 antirestriction protein -
L1O93_RS04025 (838493) 838493..839311 - 819 WP_001234706.1 DUF932 domain-containing protein -
L1O93_RS04030 (839411) 839411..839644 - 234 WP_001117561.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14162.00 Da        Isoelectric Point: 6.6312

>T232389 WP_001094449.1 NZ_CP091022:c835969-835592 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T232389 NZ_CP127277:c1574148-1573747 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13605.35 Da        Isoelectric Point: 6.4768

>AT232389 WP_024210939.1 NZ_CP091022:c836427-836059 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT232389 NZ_CP127277:c1574402-1574145 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PD61

Antitoxin

Source ID Structure
AlphaFold DB A0A826UXU4

References