Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 26634..27193 Replicon plasmid p_STEC308
Accession NZ_CP091021
Organism Escherichia coli strain STEC308

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag L1O95_RS26220 Protein ID WP_001582571.1
Coordinates 26918..27193 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I3EQ05
Locus tag L1O95_RS26215 Protein ID WP_001674495.1
Coordinates 26634..26918 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O95_RS26190 24035..24727 + 693 WP_181573844.1 fimbrial chaperone -
L1O95_RS26195 24843..25223 + 381 WP_143361631.1 hypothetical protein -
L1O95_RS26200 25374..26216 + 843 WP_235384784.1 hypothetical protein -
L1O95_RS26205 26272..26397 - 126 Protein_33 IS256 family transposase -
L1O95_RS26210 26469..26549 - 81 Protein_34 ATP-binding protein -
L1O95_RS26215 26634..26918 + 285 WP_001674495.1 ribbon-helix-helix domain-containing protein Antitoxin
L1O95_RS26220 26918..27193 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1O95_RS26225 27299..27502 + 204 Protein_37 hypothetical protein -
L1O95_RS26230 27850..28196 + 347 Protein_38 DUF6404 family protein -
L1O95_RS26235 28214..28648 - 435 Protein_39 hypothetical protein -
L1O95_RS26240 28932..29855 - 924 WP_032084040.1 hypothetical protein -
L1O95_RS26245 30748..31521 - 774 WP_032084041.1 YaiO family outer membrane beta-barrel protein -
L1O95_RS26250 31523..32104 - 582 WP_050511315.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33849 33849


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T232385 WP_001582571.1 NZ_CP091021:26918-27193 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T232385 NZ_CP127277:1239247-1239621 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT232385 WP_001674495.1 NZ_CP091021:26634-26918 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT232385 NZ_CP127277:1239053-1239250 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3EQ05

References