Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4695181..4696013 Replicon chromosome
Accession NZ_CP091020
Organism Escherichia coli strain STEC308

Toxin (Protein)


Gene name yeeV Uniprot ID A0A346GNK2
Locus tag L1O95_RS23715 Protein ID WP_032082789.1
Coordinates 4695639..4696013 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag L1O95_RS23710 Protein ID WP_001774606.1
Coordinates 4695181..4695549 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O95_RS23665 (4690213) 4690213..4690893 + 681 WP_032082725.1 WYL domain-containing protein -
L1O95_RS23670 (4691041) 4691041..4691718 + 678 WP_001097305.1 hypothetical protein -
L1O95_RS23675 (4691724) 4691724..4691957 + 234 WP_001278287.1 DUF905 family protein -
L1O95_RS23680 (4692056) 4692056..4692874 + 819 WP_044154198.1 DUF932 domain-containing protein -
L1O95_RS23685 (4692874) 4692874..4693119 + 246 WP_032082791.1 hypothetical protein -
L1O95_RS23690 (4693213) 4693213..4693692 + 480 WP_032082790.1 antirestriction protein -
L1O95_RS23695 (4693708) 4693708..4694184 + 477 WP_001297237.1 RadC family protein -
L1O95_RS23700 (4694247) 4694247..4694468 + 222 WP_000692312.1 DUF987 domain-containing protein -
L1O95_RS23705 (4694487) 4694487..4695131 + 645 WP_001774605.1 hypothetical protein -
L1O95_RS23710 (4695181) 4695181..4695549 + 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L1O95_RS23715 (4695639) 4695639..4696013 + 375 WP_032082789.1 TA system toxin CbtA family protein Toxin
L1O95_RS23720 (4696010) 4696010..4696498 + 489 WP_032082788.1 DUF5983 family protein -
L1O95_RS23725 (4696515) 4696515..4696712 + 198 WP_032082787.1 DUF957 domain-containing protein -
L1O95_RS23730 (4696809) 4696809..4697654 + 846 WP_032082786.1 DUF4942 domain-containing protein -
L1O95_RS23735 (4697725) 4697725..4699260 + 1536 WP_001609560.1 EAL domain-containing protein -
L1O95_RS23740 (4699463) 4699463..4700575 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14214.29 Da        Isoelectric Point: 8.2905

>T232383 WP_032082789.1 NZ_CP091020:4695639-4696013 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRTTGLMTRDNYRTVNNITLSKHPEKR

Download         Length: 375 bp

>T232383 NZ_CP127277:1167310-1168191 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT232383 WP_001774606.1 NZ_CP091020:4695181-4695549 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT232383 NZ_CP127277:1166690-1167313 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346GNK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References