Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 815977..816775 | Replicon | chromosome |
| Accession | NZ_CP091020 | ||
| Organism | Escherichia coli strain STEC308 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | L1O95_RS03975 | Protein ID | WP_061356740.1 |
| Coordinates | 815977..816354 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M1EW42 |
| Locus tag | L1O95_RS03980 | Protein ID | WP_032153712.1 |
| Coordinates | 816401..816775 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1O95_RS03940 (811551) | 811551..812729 | + | 1179 | WP_000094970.1 | type II secretion system protein GspL | - |
| L1O95_RS03945 (812731) | 812731..813267 | + | 537 | WP_000942786.1 | GspM family type II secretion system protein YghD | - |
| L1O95_RS03950 (813674) | 813674..814000 | - | 327 | WP_021537629.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L1O95_RS03955 (813997) | 813997..814260 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| L1O95_RS03960 (814332) | 814332..815198 | - | 867 | WP_032153714.1 | DUF4942 domain-containing protein | - |
| L1O95_RS03965 (815283) | 815283..815480 | - | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| L1O95_RS03970 (815492) | 815492..815980 | - | 489 | WP_061356741.1 | DUF5983 family protein | - |
| L1O95_RS03975 (815977) | 815977..816354 | - | 378 | WP_061356740.1 | TA system toxin CbtA family protein | Toxin |
| L1O95_RS03980 (816401) | 816401..816775 | - | 375 | WP_032153712.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| L1O95_RS03985 (816855) | 816855..817076 | - | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| L1O95_RS03990 (817145) | 817145..817621 | - | 477 | WP_061356739.1 | RadC family protein | - |
| L1O95_RS03995 (817637) | 817637..818122 | - | 486 | WP_061356738.1 | antirestriction protein | - |
| L1O95_RS04000 (818214) | 818214..819032 | - | 819 | WP_001234621.1 | DUF932 domain-containing protein | - |
| L1O95_RS04005 (819131) | 819131..819364 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| L1O95_RS04010 (819370) | 819370..820047 | - | 678 | WP_001097305.1 | hypothetical protein | - |
| L1O95_RS04015 (820195) | 820195..820875 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / iroB / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH | 691941..900248 | 208307 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14149.13 Da Isoelectric Point: 7.8045
>T232362 WP_061356740.1 NZ_CP091020:c816354-815977 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYDLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYDLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T232362 NZ_CP127276:c3784344-3783952 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13697.51 Da Isoelectric Point: 6.6240
>AT232362 WP_032153712.1 NZ_CP091020:c816775-816401 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT232362 NZ_CP127276:c3784619-3784344 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|