Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 209097..209733 Replicon chromosome
Accession NC_011567
Organism Anoxybacillus flavithermus WK1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag AFLV_RS01175 Protein ID WP_003253417.1
Coordinates 209383..209733 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID M8DWL2
Locus tag AFLV_RS01170 Protein ID WP_003398486.1
Coordinates 209097..209378 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFLV_RS01150 204772..206187 + 1416 WP_012573923.1 DEAD/DEAH box helicase -
AFLV_RS01155 206235..206597 + 363 WP_012573924.1 holo-ACP synthase -
AFLV_RS01160 206672..207691 + 1020 WP_012573925.1 outer membrane lipoprotein carrier protein LolA -
AFLV_RS01165 207787..208944 + 1158 WP_012573926.1 alanine racemase -
AFLV_RS01170 209097..209378 + 282 WP_003398486.1 hypothetical protein Antitoxin
AFLV_RS01175 209383..209733 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
AFLV_RS01180 209755..211956 + 2202 WP_012573927.1 RNA-binding transcriptional accessory protein -
AFLV_RS15410 211951..212064 - 114 WP_012573928.1 cortex morphogenetic protein CmpA -
AFLV_RS01185 212136..212591 + 456 WP_012573929.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T23236 WP_003253417.1 NC_011567:209383-209733 [Anoxybacillus flavithermus WK1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T23236 NC_011567:209383-209733 [Anoxybacillus flavithermus WK1]
TTGATTGTCAAACGTGGTGACGTGTATTTTGCCGATCTTTCTCCAGTAGTTGGATCAGAGCAAGGGGGCGTGCGCCCTGT
GCTTGTTATTCAAAATGACATCGGGAACCGTTTTAGTCCAACCGTCATCGTTGCTGCCATTACTGCGCAAATCCAAAAAG
CGAAGTTGCCTACACATGTTGAAATCGACGCAAAGCGCTACGGATTTGAACGGGACTCTGTCATTTTACTTGAACAAATT
CGGACGATTGATAAACAACGTCTGACAGATAAGATTACCCATCTAGATGATGAGATGATGGATAAAGTAGATGAAGCGTT
GCAAATTAGTCTCGGTCTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10606.17 Da        Isoelectric Point: 7.0147

>AT23236 WP_003398486.1 NC_011567:209097-209378 [Anoxybacillus flavithermus WK1]
VSESSATTEIVIRLPQALVSELDGIVKQENGSRNELIYQAMKMYIRERKKRQIREAMRRGYMEMAKINLSLASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT23236 NC_011567:209097-209378 [Anoxybacillus flavithermus WK1]
GTGTCTGAATCCAGCGCAACAACAGAAATTGTTATTCGGTTACCGCAGGCGTTAGTGAGCGAATTAGATGGAATTGTGAA
GCAAGAAAACGGCAGCCGAAATGAACTGATTTACCAAGCGATGAAAATGTACATCCGTGAGCGGAAAAAGCGTCAAATTC
GAGAAGCGATGAGACGTGGGTATATGGAGATGGCGAAAATTAATTTGTCGCTTGCGTCGGAAGCTTTTCTTGCGGAATAT
GAAGCTGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB M8DWL2

References