Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 16..575 Replicon plasmid p_STEC307
Accession NZ_CP091019
Organism Escherichia coli strain STEC307

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag L1O94_RS26025 Protein ID WP_001582571.1
Coordinates 16..291 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I3EQ05
Locus tag L1O94_RS26030 Protein ID WP_001674495.1
Coordinates 291..575 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O94_RS26025 16..291 - 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1O94_RS26030 291..575 - 285 WP_001674495.1 ribbon-helix-helix domain-containing protein Antitoxin
L1O94_RS26035 660..734 + 75 Protein_2 ATP-binding protein -
L1O94_RS26040 813..938 + 126 Protein_3 IS256 family transposase -
L1O94_RS26045 1600..1830 - 231 WP_235391146.1 hypothetical protein -
L1O94_RS26050 1982..2212 - 231 WP_235391148.1 hypothetical protein -
L1O94_RS26055 2479..3171 - 693 WP_181573844.1 fimbrial chaperone -
L1O94_RS26060 3164..5573 - 2410 Protein_7 PefC/AfrB family outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pefC 1..33842 33842
- flank IS/Tn - - 639..749 110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T232357 WP_001582571.1 NZ_CP091019:c291-16 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T232357 NZ_CP127276:3162531-3162794 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT232357 WP_001674495.1 NZ_CP091019:c575-291 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT232357 NZ_CP127276:3162246-3162527 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3EQ05

References