Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4695185..4696017 Replicon chromosome
Accession NZ_CP091018
Organism Escherichia coli strain STEC307

Toxin (Protein)


Gene name yeeV Uniprot ID A0A346GNK2
Locus tag L1O94_RS23705 Protein ID WP_032082789.1
Coordinates 4695643..4696017 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag L1O94_RS23700 Protein ID WP_001774606.1
Coordinates 4695185..4695553 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O94_RS23655 (4690217) 4690217..4690897 + 681 WP_032082725.1 WYL domain-containing protein -
L1O94_RS23660 (4691045) 4691045..4691722 + 678 WP_001097305.1 hypothetical protein -
L1O94_RS23665 (4691728) 4691728..4691961 + 234 WP_001278287.1 DUF905 family protein -
L1O94_RS23670 (4692060) 4692060..4692878 + 819 WP_044154198.1 DUF932 domain-containing protein -
L1O94_RS23675 (4692878) 4692878..4693123 + 246 WP_032082791.1 hypothetical protein -
L1O94_RS23680 (4693217) 4693217..4693696 + 480 WP_032082790.1 antirestriction protein -
L1O94_RS23685 (4693712) 4693712..4694188 + 477 WP_001297237.1 RadC family protein -
L1O94_RS23690 (4694251) 4694251..4694472 + 222 WP_000692312.1 DUF987 domain-containing protein -
L1O94_RS23695 (4694491) 4694491..4695135 + 645 WP_001774605.1 hypothetical protein -
L1O94_RS23700 (4695185) 4695185..4695553 + 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L1O94_RS23705 (4695643) 4695643..4696017 + 375 WP_032082789.1 TA system toxin CbtA family protein Toxin
L1O94_RS23710 (4696014) 4696014..4696502 + 489 WP_032082788.1 DUF5983 family protein -
L1O94_RS23715 (4696519) 4696519..4696716 + 198 WP_032082787.1 DUF957 domain-containing protein -
L1O94_RS23720 (4696813) 4696813..4697658 + 846 WP_032082786.1 DUF4942 domain-containing protein -
L1O94_RS23725 (4697729) 4697729..4699264 + 1536 WP_001609560.1 EAL domain-containing protein -
L1O94_RS23730 (4699467) 4699467..4700579 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14214.29 Da        Isoelectric Point: 8.2905

>T232355 WP_032082789.1 NZ_CP091018:4695643-4696017 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRTTGLMTRDNYRTVNNITLSKHPEKR

Download         Length: 375 bp

>T232355 NZ_CP127276:c3119302-3118418 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT232355 WP_001774606.1 NZ_CP091018:4695185-4695553 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT232355 NZ_CP127276:c3120192-3119305 [Mycobacterium tuberculosis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGCCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346GNK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References