Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1481208..1481833 Replicon chromosome
Accession NZ_CP091018
Organism Escherichia coli strain STEC307

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L1O94_RS07295 Protein ID WP_000911330.1
Coordinates 1481435..1481833 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag L1O94_RS07290 Protein ID WP_000450524.1
Coordinates 1481208..1481435 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O94_RS07265 (1477011) 1477011..1477481 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
L1O94_RS07270 (1477481) 1477481..1478053 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
L1O94_RS07275 (1478199) 1478199..1479077 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
L1O94_RS07280 (1479094) 1479094..1480128 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
L1O94_RS07285 (1480341) 1480341..1481054 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
L1O94_RS07290 (1481208) 1481208..1481435 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
L1O94_RS07295 (1481435) 1481435..1481833 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
L1O94_RS07300 (1481980) 1481980..1482843 + 864 WP_001267507.1 neutral zinc metallopeptidase -
L1O94_RS07305 (1482858) 1482858..1484873 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
L1O94_RS07310 (1484947) 1484947..1485645 + 699 WP_000679823.1 esterase -
L1O94_RS07315 (1485755) 1485755..1485955 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T232338 WP_000911330.1 NZ_CP091018:1481435-1481833 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T232338 NZ_CP127276:c2210664-2210245 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT232338 WP_000450524.1 NZ_CP091018:1481208-1481435 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT232338 NZ_CP127276:c2210933-2210673 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References