Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 12531..13090 Replicon plasmid p_STEC306
Accession NZ_CP091017
Organism Escherichia coli strain STEC306

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag L1O96_RS26110 Protein ID WP_001582571.1
Coordinates 12531..12806 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I3EQ05
Locus tag L1O96_RS26115 Protein ID WP_001674495.1
Coordinates 12806..13090 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O96_RS26080 7620..8201 + 582 WP_050511315.1 acetyltransferase -
L1O96_RS26085 8203..8976 + 774 WP_032084041.1 YaiO family outer membrane beta-barrel protein -
L1O96_RS26090 9869..10792 + 924 WP_032084040.1 hypothetical protein -
L1O96_RS26095 11076..11510 + 435 Protein_11 hypothetical protein -
L1O96_RS26100 11528..11874 - 347 Protein_12 DUF6404 family protein -
L1O96_RS26105 12222..12425 - 204 Protein_13 hypothetical protein -
L1O96_RS26110 12531..12806 - 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1O96_RS26115 12806..13090 - 285 WP_001674495.1 ribbon-helix-helix domain-containing protein Antitoxin
L1O96_RS26120 13175..13255 + 81 Protein_16 ATP-binding protein -
L1O96_RS26125 13327..13452 + 126 Protein_17 IS256 family transposase -
L1O96_RS26130 13508..14350 - 843 WP_235384784.1 hypothetical protein -
L1O96_RS26135 14501..14881 - 381 WP_143361631.1 hypothetical protein -
L1O96_RS26140 14997..15689 - 693 WP_181573844.1 fimbrial chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33843 33843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T232329 WP_001582571.1 NZ_CP091017:c12806-12531 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T232329 NZ_CP127276:1537612-1538433 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT232329 WP_001674495.1 NZ_CP091017:c13090-12806 [Escherichia coli]
MQMKNNSAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT232329 NZ_CP127276:1538426-1538662 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A5I3EQ05

References