Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1481197..1481822 Replicon chromosome
Accession NZ_CP091016
Organism Escherichia coli strain STEC306

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L1O96_RS07300 Protein ID WP_000911330.1
Coordinates 1481424..1481822 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag L1O96_RS07295 Protein ID WP_000450524.1
Coordinates 1481197..1481424 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O96_RS07270 (1477000) 1477000..1477470 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
L1O96_RS07275 (1477470) 1477470..1478042 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
L1O96_RS07280 (1478188) 1478188..1479066 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
L1O96_RS07285 (1479083) 1479083..1480117 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
L1O96_RS07290 (1480330) 1480330..1481043 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
L1O96_RS07295 (1481197) 1481197..1481424 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
L1O96_RS07300 (1481424) 1481424..1481822 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
L1O96_RS07305 (1481969) 1481969..1482832 + 864 WP_001267507.1 neutral zinc metallopeptidase -
L1O96_RS07310 (1482847) 1482847..1484862 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
L1O96_RS07315 (1484936) 1484936..1485634 + 699 WP_000679823.1 esterase -
L1O96_RS07320 (1485744) 1485744..1485944 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T232310 WP_000911330.1 NZ_CP091016:1481424-1481822 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T232310 NZ_CP127276:c639863-639450 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT232310 WP_000450524.1 NZ_CP091016:1481197-1481424 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT232310 NZ_CP127276:c640126-639860 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References