Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1999924..2000394 | Replicon | chromosome |
| Accession | NZ_CP091006 | ||
| Organism | Staphylococcus epidermidis strain R10C | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KB224_RS09665 | Protein ID | WP_001829569.1 |
| Coordinates | 2000206..2000394 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KB224_RS09660 | Protein ID | WP_002438963.1 |
| Coordinates | 1999924..2000181 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KB224_RS09620 (KB224_09620) | 1995289..1996005 | - | 717 | WP_235063493.1 | type I 3-dehydroquinate dehydratase | - |
| KB224_RS09625 (KB224_09625) | 1996166..1996588 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KB224_RS09630 (KB224_09630) | 1996772..1996909 | - | 138 | WP_162158130.1 | hypothetical protein | - |
| KB224_RS09635 (KB224_09635) | 1996939..1997126 | - | 188 | Protein_1871 | hypothetical protein | - |
| KB224_RS09640 (KB224_09640) | 1997513..1998013 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KB224_RS09645 (KB224_09645) | 1998284..1998871 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KB224_RS09650 (KB224_09650) | 1999085..1999321 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KB224_RS09655 (KB224_09655) | 1999313..1999516 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KB224_RS09660 (KB224_09660) | 1999924..2000181 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KB224_RS09665 (KB224_09665) | 2000206..2000394 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KB224_RS09670 (KB224_09670) | 2000584..2001138 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KB224_RS09675 (KB224_09675) | 2001198..2001431 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KB224_RS09680 (KB224_09680) | 2001715..2002461 | + | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KB224_RS09685 (KB224_09685) | 2002560..2002844 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KB224_RS09690 (KB224_09690) | 2002868..2003092 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KB224_RS09695 (KB224_09695) | 2003713..2003913 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1996772..1996927 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T232292 WP_001829569.1 NZ_CP091006:2000206-2000394 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T232292 NZ_CP127275:c2956018-2955695 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT232292 WP_002438963.1 NZ_CP091006:1999924-2000181 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT232292 NZ_CP127275:c2956343-2956098 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |