Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 793941..794470 Replicon chromosome
Accession NZ_CP091006
Organism Staphylococcus epidermidis strain R10C

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB224_RS03680 Protein ID WP_001829891.1
Coordinates 794108..794470 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB224_RS03675 Protein ID WP_001829931.1
Coordinates 793941..794111 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB224_RS03650 (KB224_03650) 789765..790244 + 480 WP_002457111.1 PH domain-containing protein -
KB224_RS03655 (KB224_03655) 790237..791742 + 1506 WP_029376482.1 PH domain-containing protein -
KB224_RS03660 (KB224_03660) 791729..792238 + 510 WP_002457109.1 PH domain-containing protein -
KB224_RS03665 (KB224_03665) 792286..792639 + 354 WP_029376481.1 holo-ACP synthase -
KB224_RS03670 (KB224_03670) 792706..793854 + 1149 WP_002457107.1 alanine racemase -
KB224_RS03675 (KB224_03675) 793941..794111 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB224_RS03680 (KB224_03680) 794108..794470 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB224_RS03685 (KB224_03685) 794815..795816 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB224_RS03690 (KB224_03690) 795916..796242 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB224_RS03695 (KB224_03695) 796244..796723 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB224_RS03700 (KB224_03700) 796698..797468 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232290 WP_001829891.1 NZ_CP091006:794108-794470 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232290 NZ_CP127275:c2849231-2848836 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232290 WP_001829931.1 NZ_CP091006:793941-794111 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232290 NZ_CP127275:c2849473-2849228 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References