Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1908893..1909363 Replicon chromosome
Accession NZ_CP090998
Organism Staphylococcus epidermidis strain BC1191

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KB233_RS08945 Protein ID WP_001829569.1
Coordinates 1909175..1909363 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KB233_RS08940 Protein ID WP_002438963.1
Coordinates 1908893..1909150 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB233_RS08900 (KB233_08900) 1904150..1904866 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
KB233_RS08905 (KB233_08905) 1905027..1905449 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KB233_RS08910 (KB233_08910) 1905633..1905788 - 156 WP_001829648.1 hypothetical protein -
KB233_RS08915 (KB233_08915) 1905800..1905987 - 188 Protein_1725 hypothetical protein -
KB233_RS08920 (KB233_08920) 1906481..1906981 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KB233_RS08925 (KB233_08925) 1907252..1907839 - 588 WP_001829615.1 histidine phosphatase family protein -
KB233_RS08930 (KB233_08930) 1908053..1908289 + 237 WP_002457224.1 hypothetical protein -
KB233_RS08935 (KB233_08935) 1908281..1908484 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KB233_RS08940 (KB233_08940) 1908893..1909150 + 258 WP_002438963.1 hypothetical protein Antitoxin
KB233_RS08945 (KB233_08945) 1909175..1909363 + 189 WP_001829569.1 hypothetical protein Toxin
KB233_RS08950 (KB233_08950) 1909553..1910107 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KB233_RS08955 (KB233_08955) 1910167..1910400 - 234 WP_001829664.1 hypothetical protein -
KB233_RS08960 (KB233_08960) 1910684..1911430 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KB233_RS08965 (KB233_08965) 1911529..1911813 + 285 WP_001829635.1 hypothetical protein -
KB233_RS08970 (KB233_08970) 1911837..1912061 + 225 WP_001829613.1 hypothetical protein -
KB233_RS08975 (KB233_08975) 1912682..1912882 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1905633..1912882 7249
- flank IS/Tn - - 1905633..1905788 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T232287 WP_001829569.1 NZ_CP090998:1909175-1909363 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T232287 NZ_CP127275:c2833795-2833376 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT232287 WP_002438963.1 NZ_CP090998:1908893-1909150 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT232287 NZ_CP127275:c2834016-2833792 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References