Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 803037..803566 Replicon chromosome
Accession NZ_CP090998
Organism Staphylococcus epidermidis strain BC1191

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB233_RS03695 Protein ID WP_001829891.1
Coordinates 803204..803566 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB233_RS03690 Protein ID WP_001829931.1
Coordinates 803037..803207 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB233_RS03665 (KB233_03665) 798862..799341 + 480 WP_010959254.1 PH domain-containing protein -
KB233_RS03670 (KB233_03670) 799334..800839 + 1506 WP_002457110.1 PH domain-containing protein -
KB233_RS03675 (KB233_03675) 800826..801334 + 509 Protein_724 PH domain-containing protein -
KB233_RS03680 (KB233_03680) 801382..801735 + 354 WP_002457108.1 holo-ACP synthase -
KB233_RS03685 (KB233_03685) 801802..802950 + 1149 WP_002457107.1 alanine racemase -
KB233_RS03690 (KB233_03690) 803037..803207 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB233_RS03695 (KB233_03695) 803204..803566 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB233_RS03700 (KB233_03700) 803911..804912 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB233_RS03705 (KB233_03705) 805012..805338 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB233_RS03710 (KB233_03710) 805340..805819 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB233_RS03715 (KB233_03715) 805794..806564 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232285 WP_001829891.1 NZ_CP090998:803204-803566 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232285 NZ_CP127275:c2382532-2382215 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232285 WP_001829931.1 NZ_CP090998:803037-803207 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232285 NZ_CP127275:c2382744-2382529 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References