Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 791853..792362 Replicon chromosome
Accession NZ_CP090998
Organism Staphylococcus epidermidis strain BC1191

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB233_RS03635 Protein ID WP_001829980.1
Coordinates 792153..792362 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB233_RS03630 Protein ID WP_001829893.1
Coordinates 791853..792146 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB233_RS03605 (KB233_03605) 786861..787649 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB233_RS03610 (KB233_03610) 787655..788293 + 639 WP_002505076.1 thiamine phosphate synthase -
KB233_RS03615 (KB233_03615) 788382..789254 + 873 WP_002458703.1 membrane protein insertase YidC -
KB233_RS03620 (KB233_03620) 789360..790013 - 654 WP_001829983.1 HD domain-containing protein -
KB233_RS03625 (KB233_03625) 790195..791679 - 1485 WP_002457116.1 cardiolipin synthase -
KB233_RS03630 (KB233_03630) 791853..792146 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB233_RS03635 (KB233_03635) 792153..792362 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB233_RS03640 (KB233_03640) 792505..792642 + 138 WP_001829949.1 Lmo0850 family protein -
KB233_RS03645 (KB233_03645) 792741..793952 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB233_RS03650 (KB233_03650) 794343..795416 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
KB233_RS03655 (KB233_03655) 795428..796783 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232284 WP_001829980.1 NZ_CP090998:792153-792362 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232284 NZ_CP127275:c2344542-2344108 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232284 WP_001829893.1 NZ_CP090998:791853-792146 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232284 NZ_CP127275:c2344803-2344549 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References