Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1959009..1959479 Replicon chromosome
Accession NZ_CP090993
Organism Staphylococcus epidermidis strain BC1190

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag KB234_RS09350 Protein ID WP_001829569.1
Coordinates 1959291..1959479 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag KB234_RS09345 Protein ID WP_002438963.1
Coordinates 1959009..1959266 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB234_RS09305 (KB234_09305) 1954374..1955090 - 717 WP_235063493.1 type I 3-dehydroquinate dehydratase -
KB234_RS09310 (KB234_09310) 1955251..1955673 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
KB234_RS09315 (KB234_09315) 1955857..1955994 - 138 WP_162158130.1 hypothetical protein -
KB234_RS09320 (KB234_09320) 1956024..1956211 - 188 Protein_1806 hypothetical protein -
KB234_RS09325 (KB234_09325) 1956598..1957098 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
KB234_RS09330 (KB234_09330) 1957369..1957956 - 588 WP_001829615.1 histidine phosphatase family protein -
KB234_RS09335 (KB234_09335) 1958170..1958406 + 237 WP_002457224.1 hypothetical protein -
KB234_RS09340 (KB234_09340) 1958398..1958601 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
KB234_RS09345 (KB234_09345) 1959009..1959266 + 258 WP_002438963.1 hypothetical protein Antitoxin
KB234_RS09350 (KB234_09350) 1959291..1959479 + 189 WP_001829569.1 hypothetical protein Toxin
KB234_RS09355 (KB234_09355) 1959669..1960223 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
KB234_RS09360 (KB234_09360) 1960283..1960516 - 234 WP_001829664.1 hypothetical protein -
KB234_RS09365 (KB234_09365) 1960800..1961546 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
KB234_RS09370 (KB234_09370) 1961645..1961929 + 285 WP_001829635.1 hypothetical protein -
KB234_RS09375 (KB234_09375) 1961953..1962177 + 225 WP_001829613.1 hypothetical protein -
KB234_RS09380 (KB234_09380) 1962798..1962998 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1955857..1974260 18403
- flank IS/Tn - - 1955857..1956012 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T232281 WP_001829569.1 NZ_CP090993:1959291-1959479 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T232281 NZ_CP127275:c2214671-2214327 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT232281 WP_002438963.1 NZ_CP090993:1959009-1959266 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT232281 NZ_CP127275:c2214913-2214665 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References