Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 793946..794475 Replicon chromosome
Accession NZ_CP090993
Organism Staphylococcus epidermidis strain BC1190

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB234_RS03675 Protein ID WP_001829891.1
Coordinates 794113..794475 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB234_RS03670 Protein ID WP_001829931.1
Coordinates 793946..794116 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB234_RS03645 (KB234_03645) 789770..790249 + 480 WP_002457111.1 PH domain-containing protein -
KB234_RS03650 (KB234_03650) 790242..791747 + 1506 WP_029376482.1 PH domain-containing protein -
KB234_RS03655 (KB234_03655) 791734..792243 + 510 WP_002457109.1 PH domain-containing protein -
KB234_RS03660 (KB234_03660) 792291..792644 + 354 WP_029376481.1 holo-ACP synthase -
KB234_RS03665 (KB234_03665) 792711..793859 + 1149 WP_002457107.1 alanine racemase -
KB234_RS03670 (KB234_03670) 793946..794116 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB234_RS03675 (KB234_03675) 794113..794475 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB234_RS03680 (KB234_03680) 794820..795821 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB234_RS03685 (KB234_03685) 795921..796247 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB234_RS03690 (KB234_03690) 796249..796728 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB234_RS03695 (KB234_03695) 796703..797473 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232279 WP_001829891.1 NZ_CP090993:794113-794475 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232279 NZ_CP127275:c2205854-2205435 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232279 WP_001829931.1 NZ_CP090993:793946-794116 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232279 NZ_CP127275:c2206123-2205863 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References