Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 782761..783270 Replicon chromosome
Accession NZ_CP090993
Organism Staphylococcus epidermidis strain BC1190

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB234_RS03615 Protein ID WP_001829980.1
Coordinates 783061..783270 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB234_RS03610 Protein ID WP_001829893.1
Coordinates 782761..783054 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB234_RS03585 (KB234_03585) 777769..778557 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB234_RS03590 (KB234_03590) 778563..779201 + 639 WP_002505076.1 thiamine phosphate synthase -
KB234_RS03595 (KB234_03595) 779290..780162 + 873 WP_002458703.1 membrane protein insertase YidC -
KB234_RS03600 (KB234_03600) 780268..780921 - 654 WP_001829983.1 HD domain-containing protein -
KB234_RS03605 (KB234_03605) 781103..782587 - 1485 WP_235063538.1 cardiolipin synthase -
KB234_RS03610 (KB234_03610) 782761..783054 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB234_RS03615 (KB234_03615) 783061..783270 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB234_RS03620 (KB234_03620) 783413..783550 + 138 WP_194376625.1 Lmo0850 family protein -
KB234_RS03625 (KB234_03625) 783649..784860 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB234_RS03630 (KB234_03630) 785251..786324 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB234_RS03635 (KB234_03635) 786336..787691 + 1356 WP_002470674.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232278 WP_001829980.1 NZ_CP090993:783061-783270 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232278 NZ_CP127275:c2184339-2184043 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232278 WP_001829893.1 NZ_CP090993:782761-783054 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232278 NZ_CP127275:c2184587-2184336 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References