Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2004828..2005298 | Replicon | chromosome |
| Accession | NZ_CP090989 | ||
| Organism | Staphylococcus epidermidis strain 52B | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KB232_RS09470 | Protein ID | WP_001829569.1 |
| Coordinates | 2005110..2005298 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KB232_RS09465 | Protein ID | WP_002438963.1 |
| Coordinates | 2004828..2005085 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KB232_RS09430 (KB232_09430) | 2000194..2000910 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| KB232_RS09435 (KB232_09435) | 2001071..2001493 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KB232_RS09440 (KB232_09440) | 2001677..2001814 | - | 138 | WP_032604695.1 | hypothetical protein | - |
| KB232_RS09445 (KB232_09445) | 2002418..2002918 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KB232_RS09450 (KB232_09450) | 2003189..2003776 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KB232_RS09455 (KB232_09455) | 2003988..2004224 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| KB232_RS09460 (KB232_09460) | 2004216..2004419 | - | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KB232_RS09465 (KB232_09465) | 2004828..2005085 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KB232_RS09470 (KB232_09470) | 2005110..2005298 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KB232_RS09475 (KB232_09475) | 2005488..2006041 | + | 554 | Protein_1838 | hypothetical protein | - |
| KB232_RS09480 (KB232_09480) | 2006101..2006334 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| KB232_RS09485 (KB232_09485) | 2006618..2007364 | + | 747 | WP_002495246.1 | poly-gamma-glutamate hydrolase family protein | - |
| KB232_RS09490 (KB232_09490) | 2007463..2007747 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| KB232_RS09495 (KB232_09495) | 2007771..2007995 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| KB232_RS09500 (KB232_09500) | 2008616..2008816 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1995802..2036364 | 40562 | |
| - | flank | IS/Tn | - | - | 2001677..2001832 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T232277 WP_001829569.1 NZ_CP090989:2005110-2005298 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T232277 NZ_CP127275:2182081-2182458 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT232277 WP_002438963.1 NZ_CP090989:2004828-2005085 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT232277 NZ_CP127275:2182500-2182949 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |