Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 866713..867242 Replicon chromosome
Accession NZ_CP090989
Organism Staphylococcus epidermidis strain 52B

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag KB232_RS04020 Protein ID WP_001829891.1
Coordinates 866880..867242 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag KB232_RS04015 Protein ID WP_001829931.1
Coordinates 866713..866883 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB232_RS03990 (KB232_03990) 862539..863018 + 480 WP_002457111.1 PH domain-containing protein -
KB232_RS03995 (KB232_03995) 863011..864516 + 1506 WP_002457110.1 PH domain-containing protein -
KB232_RS04000 (KB232_04000) 864503..865012 + 510 WP_002457109.1 PH domain-containing protein -
KB232_RS04005 (KB232_04005) 865060..865413 + 354 WP_002457108.1 holo-ACP synthase -
KB232_RS04010 (KB232_04010) 865478..866626 + 1149 WP_002457107.1 alanine racemase -
KB232_RS04015 (KB232_04015) 866713..866883 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KB232_RS04020 (KB232_04020) 866880..867242 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KB232_RS04025 (KB232_04025) 867587..868588 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
KB232_RS04030 (KB232_04030) 868688..869014 + 327 WP_001829952.1 anti-sigma factor antagonist -
KB232_RS04035 (KB232_04035) 869016..869495 + 480 WP_001829903.1 anti-sigma B factor RsbW -
KB232_RS04040 (KB232_04040) 869470..870240 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T232275 WP_001829891.1 NZ_CP090989:866880-867242 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T232275 NZ_CP127275:1954951-1955199 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT232275 WP_001829931.1 NZ_CP090989:866713-866883 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT232275 NZ_CP127275:1954739-1954951 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References