232272

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1657285..1657794 Replicon chromosome
Accession NZ_CP090985
Organism Staphylococcus epidermidis strain 50D

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB226_RS08075 Protein ID WP_001829980.1
Coordinates 1657285..1657494 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB226_RS08080 Protein ID WP_001829893.1
Coordinates 1657501..1657794 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB226_RS08055 (KB226_08055) 1652864..1654219 - 1356 WP_002470674.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KB226_RS08060 (KB226_08060) 1654231..1655304 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB226_RS08065 (KB226_08065) 1655695..1656906 + 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB226_RS08070 (KB226_08070) 1657005..1657142 - 138 WP_001829949.1 Lmo0850 family protein -
KB226_RS08075 (KB226_08075) 1657285..1657494 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB226_RS08080 (KB226_08080) 1657501..1657794 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB226_RS08085 (KB226_08085) 1657968..1659452 + 1485 WP_235063538.1 cardiolipin synthase -
KB226_RS08090 (KB226_08090) 1659634..1660287 + 654 WP_001829983.1 HD domain-containing protein -
KB226_RS08095 (KB226_08095) 1660393..1661265 - 873 WP_002458703.1 membrane protein insertase YidC -
KB226_RS08100 (KB226_08100) 1661354..1661992 - 639 WP_002505076.1 thiamine phosphate synthase -
KB226_RS08105 (KB226_08105) 1661998..1662786 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232272 WP_001829980.1 NZ_CP090985:c1657494-1657285 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232272 NZ_CP127275:1682840-1683157 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232272 WP_001829893.1 NZ_CP090985:c1657794-1657501 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232272 NZ_CP127275:1682541-1682843 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References