Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 478633..479103 | Replicon | chromosome |
| Accession | NZ_CP090985 | ||
| Organism | Staphylococcus epidermidis strain 50D | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | KB226_RS02330 | Protein ID | WP_001829569.1 |
| Coordinates | 478633..478821 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | KB226_RS02335 | Protein ID | WP_002438963.1 |
| Coordinates | 478846..479103 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KB226_RS02300 (KB226_02300) | 475114..475314 | + | 201 | WP_001829681.1 | cold-shock protein | - |
| KB226_RS02305 (KB226_02305) | 475935..476159 | - | 225 | WP_001829613.1 | hypothetical protein | - |
| KB226_RS02310 (KB226_02310) | 476183..476467 | - | 285 | WP_001829635.1 | hypothetical protein | - |
| KB226_RS02315 (KB226_02315) | 476566..477312 | - | 747 | WP_002438959.1 | poly-gamma-glutamate hydrolase family protein | - |
| KB226_RS02320 (KB226_02320) | 477596..477829 | + | 234 | WP_001829664.1 | hypothetical protein | - |
| KB226_RS02325 (KB226_02325) | 477889..478443 | - | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| KB226_RS02330 (KB226_02330) | 478633..478821 | - | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| KB226_RS02335 (KB226_02335) | 478846..479103 | - | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| KB226_RS02340 (KB226_02340) | 479510..479713 | + | 204 | WP_002438966.1 | sterile alpha motif-like domain-containing protein | - |
| KB226_RS02345 (KB226_02345) | 479705..479941 | - | 237 | WP_002457224.1 | hypothetical protein | - |
| KB226_RS02350 (KB226_02350) | 480155..480742 | + | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| KB226_RS02355 (KB226_02355) | 481013..481513 | - | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| KB226_RS02360 (KB226_02360) | 481900..482087 | + | 188 | Protein_441 | hypothetical protein | - |
| KB226_RS02365 (KB226_02365) | 482099..482254 | + | 156 | WP_002499031.1 | hypothetical protein | - |
| KB226_RS02370 (KB226_02370) | 482438..482860 | - | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| KB226_RS02375 (KB226_02375) | 483021..483737 | + | 717 | WP_235063493.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 482099..482254 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T232269 WP_001829569.1 NZ_CP090985:c478821-478633 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T232269 NZ_CP127275:c1385264-1384971 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT232269 WP_002438963.1 NZ_CP090985:c479103-478846 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT232269 NZ_CP127275:c1385530-1385261 [Mycobacterium tuberculosis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |