Detailed information of TA system TA232268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 253720..254215
• Replicon: chromosome
• Accession: NZ_CP090983
• Organism: Jeotgalibaca sp. MA1X17-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LZ578_RS01275
• Protein ID: WP_235145565.1
• Coordinates: 253720..253992 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LZ578_RS01280
• Protein ID: WP_235145566.1
• Coordinates: 253994..254215 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ578_RS01260 (LZ578_01260)	249449..250411	+	963	WP_235145562.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
LZ578_RS01265 (LZ578_01265)	250493..252682	+	2190	WP_235145563.1	anaerobic ribonucleoside-triphosphate reductase	-
LZ578_RS01270 (LZ578_01270)	252684..253238	+	555	WP_235145564.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
LZ578_RS12385	253447..253578	+	132	WP_255763901.1	hypothetical protein	-
LZ578_RS01275 (LZ578_01275)	253720..253992	-	273	WP_235145565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ578_RS01280 (LZ578_01280)	253994..254215	-	222	WP_235145566.1	DUF6290 family protein	Antitoxin
LZ578_RS01285 (LZ578_01285)	254453..254863	-	411	WP_235145567.1	hypothetical protein	-
LZ578_RS01290 (LZ578_01290)	254886..255215	-	330	WP_235145568.1	hypothetical protein	-
LZ578_RS01295 (LZ578_01295)	255252..255623	-	372	WP_235145569.1	hypothetical protein	-
LZ578_RS01300 (LZ578_01300)	256239..256610	-	372	WP_235145570.1	YbaN family protein	-
LZ578_RS01305 (LZ578_01305)	257073..258344	-	1272	WP_235145571.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	244655..255623	10968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-89)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10480.11 Da
• Isoelectric Point: 9.7710

>T232268 WP_235145565.1 NZ_CP090983:c253992-253720 [Jeotgalibaca sp. MA1X17-3]
MSSGYQVEFEKGAQKTLKKMDKHQSLLIMGWIKKNLVNCTDPRQHGKGLVANRSGEWRYRIGDYRLIADINDETVTILML
EIGHRKDIYQ

Nucleotide

• Length: 273 bp

>T232268 NZ_CP127275:1380848-1381279 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8490.61 Da
• Isoelectric Point: 4.6388

>AT232268 WP_235145566.1 NZ_CP090983:c254215-253994 [Jeotgalibaca sp. MA1X17-3]
MTTISLRIDSQEEKLIKEYAKSKNITVSALFRNSVLEKIEDDIDLGLYHQAMKEHKENSQSISFEDMLKELTD

Nucleotide

• Length: 222 bp

>AT232268 NZ_CP127275:1380591-1380851 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA