Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2684698..2685297 Replicon chromosome
Accession NZ_CP090978
Organism Paenibacillus sp. YPD9-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L0M14_RS11850 Protein ID WP_235122276.1
Coordinates 2684698..2685021 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L0M14_RS11855 Protein ID WP_235122277.1
Coordinates 2685022..2685297 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0M14_RS11830 (L0M14_11830) 2680232..2681404 + 1173 WP_235122272.1 MalY/PatB family protein -
L0M14_RS11835 (L0M14_11835) 2681490..2682833 - 1344 WP_235122273.1 MDR family MFS transporter -
L0M14_RS11840 (L0M14_11840) 2683080..2683247 + 168 WP_235122274.1 hypothetical protein -
L0M14_RS11845 (L0M14_11845) 2683346..2684449 - 1104 WP_235122275.1 hypothetical protein -
L0M14_RS11850 (L0M14_11850) 2684698..2685021 - 324 WP_235122276.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L0M14_RS11855 (L0M14_11855) 2685022..2685297 - 276 WP_235122277.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0M14_RS11860 (L0M14_11860) 2685456..2685890 - 435 WP_235122278.1 MarR family transcriptional regulator -
L0M14_RS11865 (L0M14_11865) 2685880..2686857 - 978 WP_235122279.1 zinc-binding alcohol dehydrogenase family protein -
L0M14_RS11870 (L0M14_11870) 2687313..2687894 - 582 WP_235122280.1 TetR/AcrR family transcriptional regulator -
L0M14_RS11875 (L0M14_11875) 2688073..2688954 + 882 WP_235122281.1 NAD(P)H-binding protein -
L0M14_RS11880 (L0M14_11880) 2689099..2689542 - 444 WP_235122282.1 cell wall hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-106)

Antitoxin

SpoVT-AbrB domain

(18-63)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11932.58 Da        Isoelectric Point: 6.2093

>T232267 WP_235122276.1 NZ_CP090978:c2685021-2684698 [Paenibacillus sp. YPD9-1]
MSADRGDLVWINFNPQAGHEQSGRRSAIVLSPKAFNETTGFVSVCPITHTVRGWGYEVLLPNGLVFNGVILTDQIKNLDW
RARRVDIVGQAPDEVVNECLDKIHTFL

Download         Length: 324 bp

>T232267 NZ_CP127275:1235923-1236297 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10226.90 Da        Isoelectric Point: 8.0463

>AT232267 WP_235122277.1 NZ_CP090978:c2685297-2685022 [Paenibacillus sp. YPD9-1]
MRERKRKEGVLSMSTTVQKWGNSLGIRIPSQIAEKIAISQGSEVDLIVGDDHSLIVIPKKKKPTLEELLAQCKMENRHEE
VTFGVEGKELL

Download         Length: 276 bp

>AT232267 NZ_CP127275:1235729-1235926 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References