Detailed information of TA system TA232265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/MazF(toxin)
• Location: 473150..473789
• Replicon: chromosome
• Accession: NZ_CP090977
• Organism: Planococcus sp. 107-1

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A098ENU8
• Locus tag: L0M13_RS02660
• Protein ID: WP_052653123.1
• Coordinates: 473439..473789 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: L0M13_RS02655
• Protein ID: WP_110925660.1
• Coordinates: 473150..473434 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0M13_RS02625 (L0M13_02625)	468880..469359	+	480	WP_235198185.1	PH domain-containing protein	-
L0M13_RS02630 (L0M13_02630)	469352..469858	+	507	WP_235198186.1	PH domain-containing protein	-
L0M13_RS02635 (L0M13_02635)	469947..470909	+	963	WP_235198187.1	PH domain-containing protein	-
L0M13_RS02640 (L0M13_02640)	470912..471519	-	608	Protein_517	rhomboid family intramembrane serine protease	-
L0M13_RS02645 (L0M13_02645)	471586..471935	+	350	Protein_518	holo-ACP synthase	-
L0M13_RS02650 (L0M13_02650)	471954..473053	+	1100	Protein_519	alanine racemase	-
L0M13_RS02655 (L0M13_02655)	473150..473434	+	285	WP_110925660.1	transcriptional regulator	Antitoxin
L0M13_RS02660 (L0M13_02660)	473439..473789	+	351	WP_052653123.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
L0M13_RS02665 (L0M13_02665)	473984..474814	+	831	WP_235198188.1	RsbT co-antagonist protein RsbRA	-
L0M13_RS02670 (L0M13_02670)	474811..475173	+	363	WP_036807366.1	STAS domain-containing protein	-
L0M13_RS02675 (L0M13_02675)	475176..475577	+	402	WP_235198189.1	anti-sigma regulatory factor	-
L0M13_RS02680 (L0M13_02680)	475590..476590	+	1001	Protein_525	PP2C family protein-serine/threonine phosphatase	-
L0M13_RS02685 (L0M13_02685)	476684..477013	+	330	WP_235198190.1	anti-sigma factor antagonist	-
L0M13_RS02690 (L0M13_02690)	477015..477485	+	471	WP_235198191.1	anti-sigma B factor RsbW	-
L0M13_RS02695 (L0M13_02695)	477463..478246	+	784	Protein_528	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12895.00 Da
• Isoelectric Point: 5.8882

>T232265 WP_052653123.1 NZ_CP090977:473439-473789 [Planococcus sp. 107-1]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDETLMEKVDEALEISVGLVKF

Nucleotide

• Length: 351 bp

>T232265 NZ_CP127275:1164001-1164882 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10674.07 Da
• Isoelectric Point: 6.6351

>AT232265 WP_110925660.1 NZ_CP090977:473150-473434 [Planococcus sp. 107-1]
VYGKSKTKEVVVKLPKQMISELTAHSDEQIQERGDYVYVSTQRVTKNIYDSHHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVRLVSGG

Nucleotide

• Length: 285 bp

>AT232265 NZ_CP127275:1163381-1164004 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A098ENU8