Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 1737474..1738036 Replicon chromosome
Accession NZ_CP090974
Organism Shewanella sp. OMA3-2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L0B17_RS07725 Protein ID WP_235089018.1
Coordinates 1737644..1738036 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag L0B17_RS07720 Protein ID WP_235089016.1
Coordinates 1737474..1737644 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0B17_RS07700 (L0B17_07700) 1733788..1735218 + 1431 WP_235089010.1 tyrosine-type recombinase/integrase -
L0B17_RS07705 (L0B17_07705) 1736149..1736526 + 378 WP_235089011.1 hypothetical protein -
L0B17_RS07710 (L0B17_07710) 1736617..1736895 + 279 WP_235089014.1 hypothetical protein -
L0B17_RS07715 (L0B17_07715) 1736990..1737315 - 326 Protein_1491 group II intron reverse transcriptase/maturase -
L0B17_RS07720 (L0B17_07720) 1737474..1737644 + 171 WP_235089016.1 acetyltransferase Antitoxin
L0B17_RS07725 (L0B17_07725) 1737644..1738036 + 393 WP_235089018.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L0B17_RS07730 (L0B17_07730) 1738572..1739825 - 1254 WP_235089027.1 tyrosine--tRNA ligase -
L0B17_RS07735 (L0B17_07735) 1739904..1740713 - 810 WP_235089029.1 LuxR family transcriptional regulator -
L0B17_RS07740 (L0B17_07740) 1741161..1742505 - 1345 Protein_1496 NADP-specific glutamate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(9-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14287.19 Da        Isoelectric Point: 3.8493

>T232264 WP_235089018.1 NZ_CP090974:1737644-1738036 [Shewanella sp. OMA3-2]
MDIICFPFERVIEINTFILETEPGMKGQVDVSKLQGALGRIDNAIVYDGLDDIFEIAAKYTASIAIAHSLPDANKRTGLI
VALEYLSLNDFELTSDNTLLADAVRDLVLGVIGESDFADILYAQYAQENQ

Download         Length: 393 bp

>T232264 NZ_CP127275:1011194-1011628 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6348.47 Da        Isoelectric Point: 10.4744

>AT232264 WP_235089016.1 NZ_CP090974:1737474-1737644 [Shewanella sp. OMA3-2]
MNKKVEAYGVNAIIRPKITATKELDLSGIYGQQIVKSETKLALRTHRKTFEKLADM

Download         Length: 171 bp

>AT232264 NZ_CP127275:1011009-1011188 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References