Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 3244684..3245483 Replicon chromosome
Accession NZ_CP090968
Organism Edwardsiella piscicida strain 18EpOKYJ

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag L1P05_RS14770 Protein ID WP_041692550.1
Coordinates 3244950..3245483 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L1P05_RS14765 Protein ID WP_041692549.1
Coordinates 3244684..3244953 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P05_RS14730 (L1P05_14730) 3240263..3240979 + 717 WP_012849890.1 SprT family zinc-dependent metalloprotease -
L1P05_RS14735 (L1P05_14735) 3241224..3241763 + 540 WP_012849891.1 transposase DNA-binding-containing protein -
L1P05_RS14740 (L1P05_14740) 3241777..3242574 + 798 Protein_2847 IS21 family transposase -
L1P05_RS14745 (L1P05_14745) 3242811..3243026 - 216 WP_012849893.1 PapB/FocB family fimbrial expression transcriptional regulator -
L1P05_RS14750 (L1P05_14750) 3243038..3243301 - 264 WP_041692548.1 DUF2442 domain-containing protein -
L1P05_RS14755 (L1P05_14755) 3243261..3243500 - 240 WP_012849894.1 DUF4160 domain-containing protein -
L1P05_RS14760 (L1P05_14760) 3243994..3244590 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
L1P05_RS14765 (L1P05_14765) 3244684..3244953 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
L1P05_RS14770 (L1P05_14770) 3244950..3245483 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
L1P05_RS14775 (L1P05_14775) 3245581..3246324 - 744 WP_012849897.1 hypothetical protein -
L1P05_RS14780 (L1P05_14780) 3248322..3248573 + 252 Protein_2855 IS21 family transposase -
L1P05_RS14785 (L1P05_14785) 3248570..3249352 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
L1P05_RS14790 (L1P05_14790) 3249457..3250260 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3212993..3258473 45480
- flank IS/Tn - - 3241777..3242658 881
- flank IS/Tn - - 3248573..3249352 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T232263 WP_041692550.1 NZ_CP090968:3244950-3245483 [Edwardsiella piscicida]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

>T232263 NZ_CP127275:837669-838097 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT232263 WP_041692549.1 NZ_CP090968:3244684-3244953 [Edwardsiella piscicida]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp

>AT232263 NZ_CP127275:837388-837645 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References