Detailed information of TA system TA023226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 582793..583397
• Replicon: chromosome
• Accession: NC_011420
• Organism: Rhodospirillum centenum SW (Rhodocista centenaria SW)

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B6IR97
• Locus tag: RC1_RS02570
• Protein ID: WP_012565775.1
• Coordinates: 583143..583397 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: RC1_RS02565
• Protein ID: WP_041785095.1
• Coordinates: 582793..583146 (-)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RC1_RS02550	578358..580028	+	1671	WP_012565769.1	MCP four helix bundle domain-containing protein	-
RC1_RS02555	580061..581308	-	1248	WP_041785093.1	alpha/beta hydrolase	-
RC1_RS02560	581774..582373	+	600	WP_012565772.1	polyhydroxyalkanoate synthesis repressor PhaR	-
RC1_RS02565	582793..583146	-	354	WP_041785095.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RC1_RS02570	583143..583397	-	255	WP_012565775.1	type II toxin-antitoxin system HicA family toxin	Toxin
RC1_RS02575	583593..585689	-	2097	WP_012565776.1	enoyl-CoA hydratase/isomerase family protein	-
RC1_RS02580	585925..586950	+	1026	WP_012565777.1	NADP-dependent oxidoreductase	-
RC1_RS02585	587021..587785	+	765	WP_012565778.1	glucose 1-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9467.97 Da
• Isoelectric Point: 10.2127

>T23226 WP_012565775.1 NC_011420:c583397-583143 [Rhodospirillum centenum SW]
MSRRDKLVDRLKGRPTDFTWDELVRLLEGLGYSEAPTGRTGGSRRRFVHATAPTIALHKPHPGSIVKMYVIEDLLRVLAE
EGLI

Nucleotide

• Length: 255 bp

>T23226 NC_011420:c583397-583143 [Rhodospirillum centenum SW]
ATGAGCCGGCGCGACAAACTGGTGGACCGGCTCAAGGGCAGGCCGACGGACTTCACCTGGGACGAACTGGTCAGGCTGCT
GGAAGGGCTGGGCTACAGCGAAGCACCGACCGGCAGGACAGGCGGGTCCCGGCGACGGTTTGTCCATGCCACCGCACCGA
CCATCGCGCTGCACAAGCCCCACCCCGGCAGCATCGTGAAGATGTACGTCATCGAAGACCTGCTGCGGGTGCTCGCCGAA
GAGGGCCTGATATGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 13144.74 Da
• Isoelectric Point: 4.7821

>AT23226 WP_041785095.1 NC_011420:c583146-582793 [Rhodospirillum centenum SW]
MSTMLEYKGYIGSVEYSDTDEVLHGRLEFIRDLVTYEGVDARGLKAAFHEAVDDYLDLCEAEGRQPDVPLKGSFNVRPGP
DLHRRAMLLARRRGETLNTVVSDALRRYLDSEAQGPA

Nucleotide

• Length: 354 bp

>AT23226 NC_011420:c583146-582793 [Rhodospirillum centenum SW]
ATGAGTACGATGCTGGAATACAAGGGATATATCGGCTCGGTCGAGTACAGCGACACGGATGAGGTGCTGCATGGCCGGCT
GGAGTTCATCCGCGATCTGGTAACCTACGAAGGCGTGGACGCAAGGGGCCTCAAGGCAGCGTTCCACGAGGCCGTGGACG
ATTATCTTGATCTGTGCGAGGCGGAGGGGCGCCAGCCCGATGTGCCGCTGAAGGGCAGCTTCAACGTCCGGCCCGGCCCC
GACCTGCACCGCCGTGCCATGCTCCTCGCCAGACGTCGGGGCGAGACCCTCAACACCGTCGTCAGTGACGCGCTGCGCCG
CTATCTCGACAGTGAGGCTCAAGGTCCGGCCTGA

Structures

Toxin

• AlphaFold DB: B6IR97