Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 3246585..3247384 Replicon chromosome
Accession NZ_CP090967
Organism Edwardsiella piscicida strain KE5

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag L1P07_RS14780 Protein ID WP_041692550.1
Coordinates 3246851..3247384 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag L1P07_RS14775 Protein ID WP_041692549.1
Coordinates 3246585..3246854 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P07_RS14740 (L1P07_14740) 3242164..3242880 + 717 WP_012849890.1 SprT family zinc-dependent metalloprotease -
L1P07_RS14745 (L1P07_14745) 3243125..3243664 + 540 WP_012849891.1 transposase DNA-binding-containing protein -
L1P07_RS14750 (L1P07_14750) 3243678..3244475 + 798 Protein_2849 IS21 family transposase -
L1P07_RS14755 (L1P07_14755) 3244712..3244927 - 216 WP_012849893.1 PapB/FocB family fimbrial expression transcriptional regulator -
L1P07_RS14760 (L1P07_14760) 3244939..3245202 - 264 WP_041692548.1 DUF2442 domain-containing protein -
L1P07_RS14765 (L1P07_14765) 3245162..3245401 - 240 WP_012849894.1 DUF4160 domain-containing protein -
L1P07_RS14770 (L1P07_14770) 3245895..3246491 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
L1P07_RS14775 (L1P07_14775) 3246585..3246854 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
L1P07_RS14780 (L1P07_14780) 3246851..3247384 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
L1P07_RS14785 (L1P07_14785) 3247482..3248225 - 744 WP_012849897.1 hypothetical protein -
L1P07_RS14790 (L1P07_14790) 3250223..3250474 + 252 Protein_2857 IS21 family transposase -
L1P07_RS14795 (L1P07_14795) 3250471..3251253 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
L1P07_RS14800 (L1P07_14800) 3251358..3252161 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3214894..3260374 45480
- flank IS/Tn - - 3243678..3244559 881
- flank IS/Tn - - 3250474..3251253 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T232250 WP_041692550.1 NZ_CP090967:3246851-3247384 [Edwardsiella piscicida]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

>T232250 NZ_CP127275:c441341-440748 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT232250 WP_041692549.1 NZ_CP090967:3246585-3246854 [Edwardsiella piscicida]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp

>AT232250 NZ_CP127275:c441759-441370 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References