Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3094634..3095297 Replicon chromosome
Accession NZ_CP090967
Organism Edwardsiella piscicida strain KE5

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag L1P07_RS14095 Protein ID WP_034167931.1
Coordinates 3094634..3095050 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag L1P07_RS14100 Protein ID WP_012849755.1
Coordinates 3095031..3095297 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P07_RS14075 (L1P07_14075) 3090565..3092298 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
L1P07_RS14080 (L1P07_14080) 3092303..3093019 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L1P07_RS14085 (L1P07_14085) 3093047..3093946 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
L1P07_RS14090 (L1P07_14090) 3094097..3094609 + 513 WP_012849753.1 flavodoxin FldB -
L1P07_RS14095 (L1P07_14095) 3094634..3095050 - 417 WP_034167931.1 protein YgfX Toxin
L1P07_RS14100 (L1P07_14100) 3095031..3095297 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
L1P07_RS14105 (L1P07_14105) 3095651..3096649 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
L1P07_RS14110 (L1P07_14110) 3096692..3097516 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
L1P07_RS14115 (L1P07_14115) 3097675..3098547 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
L1P07_RS14120 (L1P07_14120) 3099156..3099806 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T232248 WP_034167931.1 NZ_CP090967:c3095050-3094634 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T232248 NZ_CP127275:360101-360403 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT232248 WP_012849755.1 NZ_CP090967:c3095297-3095031 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT232248 NZ_CP127275:360451-360672 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References